Lifestyle Intervention for Dementia Prevention

(INSPIRE Trial)

This trial explores how lifestyle changes can help prevent dementia and improve brain health, focusing specifically on African American communities, which often face a higher impact from lifestyle-related diseases. Participants will either receive health coaching and make lifestyle changes (referred to as Lifestyle Intervention) or receive standard health education. African Americans aged 55 or older, living near Crenshaw, California, with mild or normal cognitive function, may find this trial suitable. As an unphased trial, it offers a unique opportunity to contribute to research that could enhance community health and personal well-being.

The trial information does not specify whether you need to stop taking your current medications. It is best to discuss this with the study coordinators to understand any specific requirements.

Past research has shown that lifestyle changes, such as increased exercise and a healthy diet, can lower the risk of dementia. These studies suggest that people usually find these changes manageable. Participants often reported few, if any, side effects. The focus remains on improving habits like staying active and eating well, which are safe and beneficial for most individuals. Since these changes integrate into daily life, they are considered safe for health. This makes them a good option for those aiming to boost brain health and potentially reduce the risk of dementia.¹²³⁴⁵

Researchers are excited about the Lifestyle Intervention for dementia prevention because it focuses on empowering individuals with personalized health coaching and lifestyle changes, which is a shift from the usual reliance on medication. Unlike standard treatments that may involve drugs targeting symptoms, this intervention aims to tackle the root causes by promoting healthy habits like diet, exercise, and cognitive activities. This approach has the potential to not only prevent dementia but also improve overall well-being, making it a holistic alternative to current options.

Research has shown that lifestyle changes can greatly benefit brain health. In this trial, participants in the Lifestyle Intervention arm will engage in active intervention with health coaching and lifestyle changes. Studies have found that regular exercise can reduce the risk of dementia in as little as 6–8 weeks. Another study discovered that a combination of healthy eating, exercise, socializing, and mental activities can enhance thinking skills and daily life for people with early memory issues. In many cases, significant lifestyle changes improved mental abilities and daily functioning after just 20 weeks. These changes seem to work by addressing multiple areas at once, leading to better overall brain health.²⁶⁷⁸⁹