Theta Burst Stimulation for Cognitive Impairment After Delirium

This trial explores a new method to improve thinking and focus in older adults who experienced delirium (a sudden change in mental state) after an ICU stay. It tests intermittent theta burst stimulation (iTBS), a type of brain stimulation using magnetic pulses to target brain areas related to attention and decision-making. The trial includes participants who had ICU delirium about three months ago, can speak English, and live in the community. By assessing the safety and effectiveness of this treatment, researchers aim to help people recover cognitive skills after ICU stays. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research that could enhance recovery options for future patients.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Studies have shown that intermittent theta burst stimulation (iTBS) is generally safe. This brain stimulation method uses magnetic pulses and has been safely applied to treat conditions like depression. The U.S. Food and Drug Administration (FDA) has approved iTBS for depression, confirming its safety.

A small study found that iTBS can enhance thinking and memory in people with mild cognitive impairment and Alzheimer's disease, without serious side effects. Another study involving older adults reported no major safety issues.

Unlike the standard of care for cognitive impairment after delirium, which often involves medications and cognitive therapy, intermittent theta burst stimulation (iTBS) offers a non-invasive brain stimulation technique. Researchers are excited about iTBS because it uses rapid bursts of magnetic pulses to potentially enhance brain function and improve cognitive outcomes. This technique targets specific brain regions more directly and may offer quicker results compared to traditional treatments. Additionally, iTBS could provide a novel option for patients who are resistant to or cannot tolerate medication-based therapies.

This trial will compare intermittent theta burst stimulation (iTBS) with a sham treatment to evaluate its effectiveness for cognitive impairment following delirium. Studies have shown that iTBS can enhance thinking skills, with research indicating its effectiveness in improving abilities like attention and memory in individuals with mild cognitive impairment and Alzheimer's disease. Specifically, cognitive tests have demonstrated significant improvements after using iTBS, with strong evidence supporting its role in enhancing brain function. Although researchers are still studying this treatment for cognitive issues after delirium, early results suggest it might aid recovery. Overall, the safety and promising outcomes from other conditions offer hope that iTBS could be beneficial here as well.¹²⁵⁶⁷