AGE Serum for Loose Skin

AP
Overseen ByAndrea Pacheco
Age: 18+
Sex: Female
Trial Phase: Academic
Sponsor: Goldman, Butterwick, Fitzpatrick and Groff
Must be taking: GLP-1 agonists
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests the safety and effectiveness of a new treatment, AGE Serum, for improving skin appearance in post-menopausal women taking GLP-1 agonist medication, such as Ozempic or Wegovy. The researchers aim to determine if the serum can reduce signs of aging, like fine lines and loose skin. The trial seeks women already using GLP-1 medication, with or without hormone replacement therapy (HRT). Participants should have mild to moderate signs of aging and be willing to have their skin evaluated through photos and other assessments. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research on skin health.

Do I have to stop taking my current medications for the trial?

You must continue taking your current GLP-1 agonist medication, like Ozempic, Rybelsus, or Wegovy, at a stable dose. However, you need to stop using any skincare products two weeks before the study and during the study.

Is there any evidence suggesting that AGE Serum is likely to be safe for humans?

Research has shown that AGE Serum is generally safe to use. In one study, participants using AGE Serum reported no serious side effects, indicating compatibility with various skin types. Another study found the serum safe even for individuals with noticeable age-related skin changes. Overall, these findings suggest that AGE Serum is a safe option for enhancing skin appearance.12345

Why are researchers excited about this trial?

AGE Serum is unique because it combines the effects of GLP1 receptor agonists with hormone replacement therapy (HRT) to target loose skin. While most treatments for loose skin, like topical creams or surgical procedures, focus on external application or invasive measures, AGE Serum aims to work from within by addressing underlying hormonal and metabolic factors. Researchers are excited because this approach could offer a non-invasive yet effective solution, potentially improving skin elasticity and appearance more holistically than current methods.

What evidence suggests that AGE Serum might be an effective treatment for loose skin?

Research has shown that AGE Serum can make skin firmer and more elastic. One study revealed that participants noticed significant improvements in fine lines, wrinkles, and skin firmness within eight weeks. Another study found enhancements in neck skin quality, particularly in elasticity and firmness. Additionally, a clinical study reported increases in skin elasticity by 12.5% and firmness by 20.7%. In this trial, participants in both Group A and Group B will receive AGE Serum to evaluate its effectiveness in tightening and improving the appearance of loose skin.12678

Are You a Good Fit for This Trial?

This trial is for post-menopausal women aged 45-65 who are taking a stable dose of GLP-1 agonist medication (like Ozempic, Rybelsus, or Wegovy) and have mild to moderate facial aging. Participants must be in good health and willing to complete the study. Women with certain skin conditions, recent cosmetic procedures, allergies to ingredients used, or active infections cannot join.

Inclusion Criteria

Presence of mild to moderate signs of facial aging (e.g., fine lines, laxity, dull texture) based on modified Griffith scale
I am a woman between 45 and 65 years old.
Must be willing to sign a photography release and ICF, and complete the entire course of the study
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Exclusion Criteria

I have not had ablative laser treatments on my face or neck in the past 6 months, or non-ablative laser treatments in the past 3 months.
Subjects who spray tanned or used sunless tanners in the treatment areas 1-month prior to study treatment
I have a history of connective tissue disease, Bell's Palsy, or smoking.
See 14 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants apply AGE Serum to the full face and neck twice daily

12 weeks
Visits at Week 6 and Week 12

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • AGE Serum

Trial Overview

The study tests AGE Serum's safety and effectiveness at improving loose or aging skin in post-menopausal women on GLP-1 medications—with some also on hormone replacement therapy (HRT). The results will be measured by doctor exams, participant feedback, photos, and imaging.

How Is the Trial Designed?

2

Treatment groups

Active Control

Placebo Group

Group I: Group A= On GLP1 plus HRTActive Control1 Intervention
Group II: Group B= On GLP1 OnlyPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Goldman, Butterwick, Fitzpatrick and Groff

Lead Sponsor

Trials
32
Recruited
660+

L'Oreal

Industry Sponsor

Trials
22
Recruited
11,100+

Citations

Real World Case Series: A.G.E. Interrupter Ultra Serum - PMC

However, by week 8, the patient experienced a significant improvement in fine lines (2), wrinkles (2), firmness (2), elasticity (3), laxity (2), ...

AGE Serum for Loose Skin · Info for Participants

Studies have shown that the AGE Serum, which participants in this trial will receive, can effectively firm and tighten skin, particularly on the face and neck.

An Open‐Label Study to Assess the Efficacy and Tolerability ...

Repeated measures ANOVA confirmed significant improvements across all eight neck skin quality parameters. The most pronounced improvements were ...

Anti-Aging Efficacy of a Multi-Peptides–Silybin Complex

A 56-day clinical study (n = 31) demonstrated significant improvements in wrinkle area and volume, elasticity (+12.5%), firmness (+20.7%), and dermal density (+ ...

The Effect of Local Hyaluronic Acid Injection on Skin Aging ...

According to the results of a meta-analysis, hyaluronic acid injections have been found to improve skin hydration and radiance, thus reversing ...

Preventing "GLP-1 Face": How to Protect Your Skin & Next Steps

GLP-1 face usually results from rapid weight-loss related fat loss and decreased skin elasticity, not direct skin damage from the medication ...

Evaluate the Safety and Efficacy of a Topical Serum (AGE ...

Criteria: Inclusion Criteria:~1. Presence of mild to moderate signs of facial aging (e.g., fine lines, laxity, dull texture) based on modified Griffith scale.~2 ...

A randomized, double‐blind, controlled study evaluating the ...

This study shows that Liposomal Blend is a vehicle with the ability to enhance the anti‐aging properties of the ingredients within the facial serum.