Screening Interventions for Early-Onset Colorectal Cancer

(PRECISE Trial)

This trial investigates ways to improve colorectal cancer screening for younger Veterans, specifically those aged 45-49. It aims to develop a method to identify individuals at higher risk of early-onset colorectal cancer and encourage preventive steps. The trial includes different groups: some patients will receive information about their risk (patient intervention), some providers will be informed (PCP intervention), and some both. It seeks participants who have not had a recent colonoscopy or FIT test and have no history of colorectal cancer. As an unphased trial, this study offers participants the chance to contribute to innovative research that could enhance early detection and prevention strategies for colorectal cancer.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research has shown that having a primary care doctor can improve outcomes in colorectal cancer (CRC) screening. Studies indicate that patients with a primary care doctor are 54% less likely to receive a late-stage CRC diagnosis compared to those without one. This involvement in screening proves beneficial and well-received.

Providing patients with personal support and information about screening is safe and poses no known issues. Involving both patients and their doctors together appears promising, leading to more discussions about CRC screening without any reported negative effects.

Researchers are excited about this trial because it explores innovative ways to improve early detection of colorectal cancer, particularly in younger populations. Unlike traditional approaches that rely heavily on patient-initiated screenings or physician recommendations, this trial tests several new intervention strategies: one that involves direct patient engagement, another that targets primary care providers (PCPs), and a combined approach involving both. By exploring these different methods, researchers hope to identify the most effective way to encourage timely screenings and potentially catch cancer earlier, ultimately improving patient outcomes.

Research has shown that having a regular primary care doctor can greatly improve outcomes for early-onset colorectal cancer. Studies have found that patients with a regular doctor are 54% less likely to be diagnosed with advanced colorectal cancer, highlighting the importance of doctors in screening and prevention. In this trial, participants may receive different interventions: some will receive a patient-focused intervention, others a primary care provider (PCP) intervention, and some both. These interventions aim to enhance early detection and improve survival chances. Findings suggest that both regular doctor visits and patient actions can help catch the cancer early and improve survival chances.¹⁴⁶⁷⁸