Artificial Intelligence for Colonic Polyps
(CADx-Prosp Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
Computer-aided image-enhanced endoscopy can predict the nature of colorectal polyps with over 90% accuracy. This technology uses artificial intelligence (AI) to analyze video recordings of polyps, learning to make diagnoses in real-time. This means that doctors can get immediate predictions about small polyps during the procedure, reducing the need for separate pathology exams and saving costs, ultimately improving patient care.
Human and AI interactions are complex and a framework to reap synergistic effects CADx systems when used by humans to harness optimal performance needs to be established. AI solutions in medicine are usually developed to be used as assistive devices, however, then they rely on humans to correct AI errors. Optical polyp diagnosis is a complex task. Non experts usually achieve diagnostic accuracy in 70-80%. CADx systems have a similar diagnostic accuracy when used autonomously. Clinical evaluation of CADx systems showed that CADx assisted OD performs equally to the operator performance when using non CADx assisted OD. To harness a benefit of clinical CADx implementation we would have to find a way that synergies between human and CADx come into play to eliminate cases in which CADx assisted and/ or human OD results in low diagnostic accuracy and also addresses the problem of serrated polyp recognition.
Who Is on the Research Team?
Daniel von Renteln, MD
Principal Investigator
University of Montreal Medical Center (CHUM)
Are You a Good Fit for This Trial?
This trial is for people who need a full colonoscopy. There are no other major restrictions listed.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Endoscopists perform optical diagnosis using both standard and image-enhanced endoscopy, followed by CADx-assisted diagnosis
Follow-up
Participants are monitored for diagnostic accuracy and cost-effectiveness of optical diagnosis methods
What Are the Treatments Tested in This Trial?
Interventions
- CADx (AI) system
Trial Overview
The study compares two ways to diagnose colon polyps during endoscopy: one uses an AI system (CADx) alone, and the other has doctors use the AI as an assistant. The goal is to see which method gives more accurate results in real-time.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
The endoscopist will make an optical diagnosis (OD) prediction for all small polyps (up to 10 mm) in white light (WL). Then, the endoscopist will make another OD prediction using image enhanced endoscopy (IEE) modes. After that, CADx will be activated in the IEE mode and a CADx prediction will be documented. Finally, after seeing the CADx prediction, the endoscopist will make a final prediction, which can agree or disagree with the autonomous CADx one. Polyps will be resected and sent to a pathology lab, where a pathologic diagnosis (blinded to the endoscopist's predictions) will be rendered.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Centre hospitalier de l'Université de Montréal (CHUM)
Lead Sponsor
Roupen Djinbachian, MD
Collaborator
Mahsa Taghiakbari, MD PHD
Collaborator
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