Chewing Gum for Colon Cancer Screening
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial examines whether chewing sugar-free gum can make colonoscopy preparation easier and more tolerable. Colonoscopies help detect and remove polyps before they become cancerous, but the preparation can be challenging due to its taste and side effects. Researchers aim to determine if gum chewing during preparation improves participants' experience, increasing the likelihood of completion. This trial suits individuals scheduled for a routine colonoscopy who have not undergone major abdominal surgeries or have jaw issues. As an unphased trial, it offers participants the opportunity to contribute to research that could enhance the comfort of colonoscopy preparation for everyone.
Do I have to stop taking my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. However, if you are using GI prokinetics (medications that help move food through the digestive tract), you cannot participate in the trial.
What prior data suggests that chewing sugar-free gum is safe during bowel preparation?
Research has shown that chewing sugar-free gum during colonoscopy preparation is generally safe. A study from China found that while gum chewing did not improve bowel cleanliness, it made the process more enjoyable for patients. Another study reported that patients who chewed gum experienced less discomfort, nausea, and vomiting, and perceived the preparation as taking less time.
The gum used in these studies was non-medicated and sugar-free, containing no active ingredients that could be harmful. Patients were advised not to swallow the gum and to stop chewing if they experienced any discomfort. Overall, chewing gum during bowel prep appears to be a safe and well-tolerated option for most people.12345Why are researchers excited about this trial?
Researchers are excited about using chewing gum as part of colon cancer screening protocols because it offers a simple, non-invasive addition to standard bowel preparations. Unlike traditional methods that rely solely on large volumes of laxatives, chewing gum may enhance bowel preparation by stimulating digestive processes naturally. This approach could potentially improve patient comfort and compliance, making the screening experience more tolerable. By incorporating something as familiar as chewing gum, researchers hope to find out if it can effectively aid in cleaning the colon before a colonoscopy.
What evidence suggests that chewing gum could make bowel preparation more tolerable for colonoscopy?
Research has shown that chewing sugar-free gum does not affect bowel cleanliness for a colonoscopy. However, studies have found that it can make the preparation process more comfortable for patients. In this trial, some participants will chew gum during their bowel preparation, while others will not. Many patients report feeling more satisfied with their colonoscopy prep when they chew gum. Although it doesn't improve bowel cleanliness, chewing gum is easy, safe, and might make the experience more pleasant. This could encourage more people to complete their colonoscopy prep.23678
Are You a Good Fit for This Trial?
This trial is for adults aged 45-75 who are scheduled for an outpatient colonoscopy and can give consent. People can't join if they are pregnant, have trouble chewing or swallowing, use certain gut medications, have major abdominal surgeries (except appendix/gallbladder removal), allergies to prep or gum, cognitive issues, or TMJ problems.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Bowel Preparation
Participants undergo split-dose bowel preparation with or without chewing gum
Colonoscopy Procedure
Participants undergo colonoscopy to assess bowel cleansing quality and other metrics
Follow-up
Participants are monitored for adverse events and outcomes post-procedure
What Are the Treatments Tested in This Trial?
Interventions
- Chewing Sugar-Free Gum
Trial Overview
The study compares standard bowel prep alone versus standard bowel prep plus chewing sugar-free gum during the process. Participants are randomly assigned to either group to see if gum makes the preparation easier and more tolerable before a colonoscopy.
How Is the Trial Designed?
4
Treatment groups
Experimental Treatment
Active Control
Participants randomized to the experimental arm will chew one piece of sugar-free gum for approximately 15-20 minutes, 30 minutes before starting the first dose of split-dose bowel preparation and again 30 minutes after the second dose. The gum is sugar-free and non-medicated. Participants will be instructed not to swallow the gum and to discontinue chewing if they experience discomfort. All participants will receive standard bowel preparation (either 4L PEG or 2L PEG + ascorbate, prescribed according to clinical indication). The endoscopist performing the colonoscopy will remain blinded to group assignment.
Arm Description: Participants randomized to the experimental arm will chew one piece of sugar-free gum for approximately 15-20 minutes, 30 minutes before starting the first dose of split-dose bowel preparation and again 30 minutes after the second dose. The gum is sugar-free and non-medicated. Participants will be instructed not to swallow the gum and to discontinue chewing if they experience discomfort. All participants will receive standard bowel preparation (either 4L PEG or 2L PEG + ascorbate, prescribed according to clinical indication). The endoscopist performing the colonoscopy will remain blinded to group assignment.
Participants in the control arm will undergo standard split-dose bowel preparation (4L PEG) according to clinical indication, without chewing gum before or after the preparation. Endoscopists will be blinded to participant group assignment.
Arm Description: Participants in the control arm will undergo standard split-dose bowel preparation (2L PEG + ascorbate) according to clinical indication, without chewing gum before or after the preparation. Endoscopists will be blinded to participant group assignment.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Maryland, Baltimore
Lead Sponsor
Citations
The Effect of Chewing Sugar-Free Gum to Improve Bowel ...
Chewing free sugar gum after colorectal surgeries can significantly improve the recovery of bowel motion by accelerating the time to first auscultation to bowel ...
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ctv.veeva.com
ctv.veeva.com/study/impact-of-chewing-gum-on-bowel-preparation-in-patients-undergoing-colonoscopyImpact of Chewing Gum on Bowel Preparation in Patients ...
Chewing gum has been proposed as a simple and low-cost adjunct that could improve tolerance to bowel preparation. The act of chewing gum ...
Effect of Gum Chewing or Walking on Bowel Prep Quality ...
The results of this study will contribute to a better understanding of the impact of chewing gum and walking exercise before colonoscopy on the quality of bowel ...
Impact of gum chewing on the quality of bowel preparation ...
The findings of this randomized controlled trial suggest that gum chewing before colonoscopy does not improve the quality of bowel preparation. Although it is ...
Impact of gum chewing on the quality of bowel preparation ...
This study indicates that gum chewing does not improve the quality of bowel preparation for colonoscopy, but it can improve patients' satisfaction with the ...
Efficacy and Safety of Gum Chewing in Adjunct to High-Dose ...
In conclusion, patients who were instructed to chew gum during the colonoscopy bowel cleansing period demonstrated better bowel cleaning and lower discomfort ...
Impact of gum chewing on the quality of bowel preparation ...
This study indicates that gum chewing does not improve the quality of bowel preparation for colonoscopy, but it can improve patients' satisfaction.
Impact of Chewing Gum on Bowel Preparation in Patients ...
Chewing sugar-free gum is a simple, low-cost, and safe intervention that may make the preparation process easier. One study from China found that chewing gum ...
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