Dietary Therapy for Ulcerative Colitis
(Sulfur-UC Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This study aims to test whether a short liquid-based diet, followed by a low-sulfur eating plan, is safe, manageable, and helpful for people with mild to moderate ulcerative colitis. Investigators want to see if this approach can improve gut health, lower inflammation, and reduce symptoms. Investigators will also test breath samples as an easy, non-invasive way to track gut bacteria activity and disease changes. Investigators believe this diet plan can reduce harmful gut bacteria that produce irritating sulfur compounds, leading to better gut health and measurable improvements that can be detected through breath testing.
Who Is on the Research Team?
Natasha Haskey, RD, PhD
Principal Investigator
University of British Columbia
Are You a Good Fit for This Trial?
This trial is for adults aged 19-70 with mild to moderate ulcerative colitis who have had stable treatment (no recent changes) and are not currently using steroids. Participants should be considering a change in their medication due to ongoing symptoms.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Elemental Diet
Participants consume a novel elemental formula as their sole source of nutrition
Reduced Sulfur Diet
Participants follow a reduced sulfur diet designed to limit dietary sources of sulfur-containing compounds
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Elemental formula (mBiota Elemental)
- Reduced Sulfur diet
Trial Overview
The study compares three diets: participants' usual diet, a short-term liquid elemental formula, and then a low-sulfur diet. Researchers will use breath tests to see how these diets affect gut health and inflammation in people with ulcerative colitis.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Participants will consume a novel elemental formula (mBiota Elemental, Good LFE, Santa Monica, CA) as their sole source of nutrition for two weeks. followed by a 10-week reduced sulfur diet. The reduced sulfur diet is designed to limit dietary sources of sulfur-containing compounds that may contribute to hydrogen sulfide production by the gut microbiota.
Participants will complete a 2-week elemental diet intervention followed by a 10-week habitual diet. Participants will be instructed to resume and maintain their usual dietary intake without specific sulfur-restriction recommendations.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of British Columbia
Lead Sponsor
University of Calgary
Collaborator
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