Brain Stimulation + Cognitive Training for Mild Cognitive Impairment

(RISE pilot Trial)

This trial tests a treatment combining brain stimulation and cognitive training for individuals with mild cognitive impairment (MCI). The brain stimulation, known as accelerated intermittent theta burst stimulation (iTBS), is non-invasive and aims to enhance memory and thinking skills. Participants will also engage in computer-based exercises to improve cognitive function. Individuals with MCI who maintain a stable medication routine and received a diagnosis within the past year may be suitable candidates. The trial aims to determine if this approach effectively improves daily life functions in those with MCI. As an unphased trial, it provides a unique opportunity to explore innovative treatments that could enhance cognitive health.

You can continue taking your current medications if they have been at a stable dose for at least 4 weeks before joining the trial. However, daily or weekly use of anticholinergic or sedative medications is not allowed.

Research has shown that accelerated intermittent theta burst stimulation (iTBS) is usually safe and well-tolerated. One study found that iTBS in people with mild cognitive impairment (MCI) did not cause serious side effects. Another study reported that personalized iTBS was both safe and provided cognitive benefits for patients with mild Alzheimer's disease.

Computerized cognitive training (CCT) is also considered safe. Previous studies highlight that CCT can improve mental abilities in older adults without causing harmful effects. A review of several studies shows that CCT enhances overall brain function in people with MCI.

Unlike the standard of care for mild cognitive impairment, which often involves medications like cholinesterase inhibitors, the treatment in question uses a non-invasive brain stimulation technique called accelerated intermittent theta-burst stimulation (iTBS) combined with cognitive training. Researchers are excited about this approach because iTBS is thought to enhance brain plasticity and improve cognitive function more directly by stimulating specific brain regions. Additionally, the treatment's accelerated nature means it could potentially deliver benefits in a shorter time frame compared to traditional therapies. This combination of brain stimulation with cognitive training offers a novel way to potentially boost cognitive abilities in those with mild cognitive impairment.

Studies have shown that accelerated intermittent theta burst stimulation (iTBS) can improve thinking and memory in people with mild cognitive impairment (MCI). Research indicates that this method may enhance brain function and skills like memory and problem-solving. In this trial, one group of participants will receive iTBS combined with computerized cognitive training (CCT), which has been found to further increase brain activity and the brain's ability to change and adapt. Another group will receive iTBS with sham CCT. CCT alone has also been effective in improving different types of memory and overall brain function in those with MCI. This combination is being explored because both treatments show promise in boosting cognitive abilities.²⁴⁶⁷⁸