AP-Brain for Cognitive Functioning

MM
Overseen ByMarc Moulin

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests the safety and effectiveness of AP-Brain, a supplement with hydrolyzed collagen, for improving memory in middle-aged and older adults. Participants will take varying doses of AP-Brain or a placebo to assess its impact on cognitive function. It is suitable for individuals aged 40-79 who have noticed memory problems but do not have dementia or other major cognitive issues. Participants must maintain their lifestyle habits and avoid certain activities, such as high caffeine intake and intense exercise, before study visits.

As an unphased trial, this study allows participants to contribute to groundbreaking research on memory improvement.

Will I have to stop taking my current medications?

The trial does not specify if you must stop taking your current medications, but it does require you to maintain your current lifestyle habits, including medications, as much as possible. However, if your medications might impact the study's safety or effectiveness, you may need to adjust them.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that AP-Brain, which contains a type of processed protein called hydrolyzed collagen, is generally safe for people. One study found that this kind of collagen, like the one in AP-Brain, did not cause any adverse side effects, indicating that many people can use it without issues. Another study also found that hydrolyzed collagen is safe and easily processed by the body. These findings are encouraging for those considering joining the trial. However, since individual responses can vary, consulting a doctor before deciding to participate is advisable.12345

Why are researchers excited about this trial?

Most treatments for cognitive decline focus on neurotransmitter balance, like those that increase acetylcholine levels. However, AP-Brain is unique because it uses hydrolyzed collagen, a completely different approach. Researchers are excited because collagen could offer a novel way to support brain health and cognitive function. Unlike neurotransmitter-focused treatments, AP-Brain's various doses (1g, 3g, and 5g) might provide flexible options for different needs. This represents a fresh perspective on enhancing cognitive health, potentially offering benefits through collagen's impact on brain structure and support.

What evidence suggests that AP-Brain might be an effective treatment for cognitive function?

Studies have shown that collagen hydrolysates, a type of protein, can positively affect brain function. One clinical study indicated that taking 5 grams of collagen peptides daily improved memory and thinking skills. Another study found changes in brain structure and language skills after consuming collagen hydrolysates. Participants also reported feeling more alert and energetic. These findings suggest that AP-Brain, which contains hydrolyzed collagen, might help improve memory and thinking abilities.36789

Who Is on the Research Team?

DC

David Crowley

Principal Investigator

KGK Science Inc.

Are You a Good Fit for This Trial?

This trial is for healthy adults aged 40-79 with self-reported memory issues. Women must be non-childbearing, either post-menopausal, sterilized, or using reliable contraception. Men should have a vasectomized partner or agree to use contraception.

Inclusion Criteria

Or
I am not heterosexual or I agree to use contraception if I plan to have a heterosexual partner.
I have memory problems with a score of 6 or more from the screening.
See 7 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants consume AP-Brain at 1 g, 3 g, or 5 g, or Placebo and complete memory assessment questionnaires

8 weeks
Weekly visits (in-person or virtual)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • AP-Brain

Trial Overview

The trial tests AP-Brain's effects on cognitive function at doses of 1g, 3g, and 5g compared to a placebo in middle-aged and older adults with memory complaints. Participants will take the supplement and complete memory assessments.

How Is the Trial Designed?

4

Treatment groups

Experimental Treatment

Placebo Group

Group I: AP-Brain (5g)Experimental Treatment1 Intervention
Group II: AP-Brain (3g)Experimental Treatment1 Intervention
Group III: AP-Brain (1g)Experimental Treatment1 Intervention
Group IV: PlaceboPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Rousselot BVBA

Lead Sponsor

Trials
8
Recruited
220+

KGK Science Inc.

Industry Sponsor

Trials
82
Recruited
6,400+

Najla Guthrie

KGK Science Inc.

Chief Executive Officer since 1997

Research career at the Centre for Human Nutrition, University of Western Ontario

Dr. Bibiane Zakaria

KGK Science Inc.

Chief Medical Officer since 2023

MD from an unspecified institution

Citations

Effects of Collagen Hydrolysates on Human Brain Structure ...

Daily ingestion of CH changed brain structure and improved language cognitive function. Keywords: collagen hydrolysate, cognitive health, magnetic resonance ...

(PDF) Effects of Collagen Hydrolysates on Human Brain ...

This study investigated the effects of collagen hydrolysates (CH) on language cognitive function and brain structure.

Collagen peptides supplementation improves function, ...

In a clinical pilot study, Koizumi et al., (2019) found that CP supplementation of 5 g/d for 4 weeks improved cognitive function and memory, as ...

Effects of a Jellyfish Collagen-Based Amino Acid ...

Though not analyzable, over half the individuals throughout the study period voluntarily reported positive outcomes, especially related to alertness, energy, ...

Collagen peptide supplementation before bedtime reduces ...

CP supplementation did not influence sleep quantity, latency, or efficiency, but reduced awakenings and improved cognitive function in physically active males ...

A Clinical Trial to Investigate the Safety and Efficacy of AP ...

The goal of this clinical trial is to investigate the safety and efficacy of AP-Brain on cognitive function at varying dosages in healthy ...

AP-Brain for Cognitive Functioning · Info for Participants

The goal of this clinical trial is to safety and efficacy of AP-Brain on cognitive function at varying dosages in healthy middle-aged and ...

The Efficacy and Safety of CollaSel Pro® Hydrolyzed ...

Accordingly, CollaSel Pro® hydrolyzed collagen peptide can be considered a well-tolerated, safe product that effectively improves dermal health ...

Journal ofClinical Research and Reports AUCTORES

Importantly, no adverse side effects were reported, suggesting the supplement could be safely used by a large segment of the global population.