Empower LCS/Call+ for Lung Cancer Screening

(Empower LCS+ Trial)

Not yet recruiting at 57 trial locations
GS
Overseen ByGelareh Sadigh, MD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of California, Irvine
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to boost lung cancer screening rates using new strategies, such as educational materials and reminders. It targets individuals who qualify for lung cancer screening based on guidelines, specifically those who have smoked for many years and either continue to smoke or have quit recently. Participants will receive either usual care with brochures or additional support through the Empower LCS/Call+ program, a telephone navigation service. The trial will evaluate whether these methods increase screening rates and determine the most effective approach. If lung cancer screening remains incomplete after the initial steps, additional phone support will help overcome any obstacles. As an unphased trial, this study provides a unique opportunity to enhance lung cancer screening strategies for future patients.

What prior data suggests that the Empower LCS/Call+ intervention is safe for lung cancer screening?

Research has shown that the Empower LCS/Call+ program, which provides phone support, is easy for patients to manage. Studies have found that participants using this program for lung cancer screening experience no major side effects. This indicates the program's safety for those considering joining a clinical trial. The program aims to help individuals complete their lung cancer screenings without causing harm or discomfort.12345

Why are researchers excited about this trial?

Researchers are excited about the Empower LCS/Call+ trial because it aims to enhance lung cancer screening participation through unique methods. Unlike the usual care, which typically involves standard education and reminders, the Empower LCS/Call+ approach offers telephone navigation specifically for those who do not initially respond. This personalized, proactive outreach could significantly increase screening rates, leading to earlier detection of lung cancer when it's most treatable. By potentially improving participation in lung cancer screenings, this method could transform current practices and lead to better outcomes for patients.

What evidence suggests that the Empower LCS/Call+ intervention could be effective for improving lung cancer screening?

Research has shown that the Empower LCS/Call+ program, tested in this trial, can increase lung cancer screening rates. Participants may receive the Empower LCS/Call+ intervention, which includes patient navigation. This component significantly boosts the number of completed lung cancer screenings. For example, one study found that navigation increased screening rates in underserved communities. Additionally, Empower LCS helps patients understand the risks and benefits of lung cancer, leading to more discussions and completed screenings. Overall, this approach aims to make lung cancer screening easier and more effective for those who need it most.12346

Who Is on the Research Team?

IG

Ilana Graetz, PhD

Principal Investigator

Emory University

GS

Gelareh Sadigh

Principal Investigator

University of California, Irvine

Are You a Good Fit for This Trial?

This trial is for adults who are eligible for lung cancer screening based on current U.S. guidelines, typically people with a history of heavy smoking and within certain age ranges. Participants will be recruited from UC Irvine Health and Emory Healthcare.

Inclusion Criteria

I am 50-80 years old and have smoked for 20 years or more.
Must speak English or Spanish
Able and willing to provide informed consent
See 2 more

Exclusion Criteria

I have been diagnosed with another cancer in the past 12 months.
Have a chest CT or LDCT in the last 12 months
I have a diagnosis of Alzheimer's disease in my medical records.
See 2 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Survey

Participants complete a baseline survey to assess initial knowledge and attitudes towards lung cancer screening

1 week
1 visit (virtual)

Intervention

Participants receive either enhanced usual care or the Empower LCS/Call+ intervention, which includes educational materials, reminders, and information about resources

4 months
Ongoing virtual support

Follow-up Surveys

Participants complete follow-up surveys to assess changes in knowledge, attitudes, and screening behaviors

4 months
2 visits (virtual)

Follow-up

Participants are monitored for completion of lung cancer screening and other outcomes

8 months

What Are the Treatments Tested in This Trial?

Interventions

  • Call+ Telephone Navigation
  • Empower LCS

Trial Overview

The study compares usual care to an intervention called Empower LCS/Call+, which includes educational materials, reminders, resource information, and extra phone support to help patients complete lung cancer screening. Participants are randomly assigned to each group.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: Empower LCS/Call+Experimental Treatment3 Interventions
Group II: Enhanced Usual CareActive Control2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of California, Irvine

Lead Sponsor

Trials
580
Recruited
4,943,000+

Citations

Empowering Patients' Lung Cancer Screening Uptake ...

The results of this study will help determine the feasibility, acceptability, and preliminary effectiveness of the Empower LCS/Call+ ...

Effect of Patient Navigation on Completion of Lung Cancer ...

Specifically, navigation may improve rates of screening and follow-up for abnormal results; it can also decrease disparities in care, particularly for breast ...

Empowering Patients' Lung Cancer Screening Uptake ...

The results of this study will help determine the feasibility, acceptability, and preliminary effectiveness of the Empower LCS/Call+ ...

A Single-Arm Pilot Feasibility Clinical Trial

Results In all, 70 patients enrolled. Empower LCS targets patients' lung cancer perceived risk, severity, and perceived LCS benefits through ...

Empowering Patients' Lung Cancer Screening Uptake ...

The results of this study will help determine the feasibility, acceptability, and preliminary effectiveness of the Empower LCS/Call+ ...

Tele-Navigation for Lung Cancer Screening

Studies have found that phone-based guidance increases the likelihood of patients completing their screening without major side effects, indicating the program ...