Bioresorbable Nasal Dressing for Sinusitis

(ENHANCE II Trial)

Enrolling by invitation at 8 trial locations
BI
SG
Overseen BySarah Grace Dennis-Little, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Polyganics BV
Stay on Your Current MedsYou can continue your current medications while participating
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The primary objective of the study is to evaluate the safety and effectiveness of OCEAN as an adjunct aid in wound healing after nasal/sinus surgery and to demonstrate that OCEAN is non-inferior compared to a steroid-eluting sinus stent.

Are You a Good Fit for This Trial?

This trial is for adults (18+) with chronic sinusitis who are scheduled for sinus surgery on both sides of the nose. Participants must not be pregnant, must agree to avoid pregnancy during the study, and need to be able to follow study instructions and give consent.

Inclusion Criteria

I am willing and able to follow the study's requirements.
I am 18 years old or older.
I am scheduled for sinus surgery on both sides, including complete ethmoidectomy.
See 4 more

What Are the Treatments Tested in This Trial?

Interventions

  • OCEAN
  • Steroid-eluting sinus stent

Trial Overview

The study compares a new bioresorbable nasal dressing called OCEAN with an existing steroid-releasing sinus stent. Both are used after sinus surgery to help healing. The goal is to see if OCEAN works as well and is as safe as the current standard.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: OCEANExperimental Treatment1 Intervention
Group II: Steroid-eluting Sinus StentActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Polyganics BV

Lead Sponsor

Trials
6
Recruited
450+

NAMSA

Collaborator

Trials
55
Recruited
21,500+