Aerobic Exercise for Pediatric Chronic Pain

This trial explores whether a single session of intense aerobic exercise can reduce pain sensitivity and improve daily functioning in young people. It targets youth who struggle to attend school, play sports, or socialize due to chronic pain. Participants, whether they have a chronic pain syndrome or not, will perform the same exercise to assess its effects. This trial suits youth dealing with chronic pain syndrome who can safely exercise on a treadmill. As an unphased trial, it offers a unique opportunity for participants to contribute to understanding how exercise affects chronic pain in youth.

The trial does not specify if you need to stop taking your current medications, but you cannot participate if you've used opioids in the last week.

Previous studies have found aerobic exercise safe and feasible for children with long-term health issues. Research shows that exercise can reduce pain and increase participation in daily activities. For example, children with juvenile idiopathic arthritis (a type of joint swelling) have safely participated in exercise programs. Another study suggested that physical activity is safe and beneficial for those with sickle cell disease, a condition affecting blood cells. So far, exercise has been well-tolerated and has not shown any harmful effects in these groups.¹²³⁴⁵

Unlike standard treatments for pediatric chronic pain, which often include medications like NSAIDs, opioids, or anticonvulsants, aerobic exercise offers a drug-free alternative that could potentially enhance pain management. Researchers are excited about this approach because exercise is known to release endorphins, the body's natural pain relievers, and improve overall physical function and mood. Additionally, aerobic exercise might provide immediate benefits after just a single session, unlike some medications that take longer to show effects. This method could be particularly appealing for young patients, offering a holistic and active way to manage chronic pain without the side effects associated with pharmaceuticals.

This trial will compare the effects of aerobic exercise on youth with chronic pain syndromes to those without. Studies have shown that aerobic exercise can reduce pain sensitivity and help children with chronic pain engage more easily in daily activities. Research suggests that aerobic exercise can lead to less pain and improved mood. However, some studies have found mixed results, indicating that effectiveness can vary. Despite this, exercise is generally considered safe and beneficial for most children with chronic conditions. While results aren't entirely clear, promising evidence suggests that aerobic exercise could be a helpful tool in managing chronic pain in children.¹³⁶⁷⁸