100 Participants NeededMy employer runs this trial

Transcranial Direct Current Stimulation for Chronic Pain

SF
SR
Overseen BySheila Rauch, PhD
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to determine if Transcranial Direct Current Stimulation (tDCS) can reduce chronic pain for participants in a specialized mental health program. Participants will undergo short, daily tDCS sessions for two weeks to assess any changes in pain levels and quality of life. It suits individuals already in the program who frequently experience significant pain and have a primary care or pain management doctor. As an unphased trial, this study provides participants the chance to explore a novel approach to managing chronic pain, potentially enhancing their quality of life.

Do I have to stop taking my current medications for the trial?

Yes, you may need to stop taking certain medications to join the trial. Specifically, you cannot use sodium channel blockers, certain antidepressants, anti-epileptic medications, calcium channel blockers, or N-Methyl-D-aspartate receptor antagonists.

What prior data suggests that this technique is safe for reducing chronic pain?

Research has shown that Transcranial Direct Current Stimulation (tDCS) is generally safe for people. A large review of 162 clinical trials found that tDCS is safe for individuals with various types of chronic pain. Most participants did not experience serious side effects. Some reported mild tingling or itching where the device touched their skin. This suggests that tDCS is a safe option for managing chronic pain.12345

Why are researchers excited about this trial?

Transcranial Direct Current Stimulation (tDCS) is unique because it offers a non-invasive way to manage chronic pain by using a mild electrical current to stimulate specific areas of the brain. Unlike traditional pain treatments like opioids or NSAIDs, which focus on alleviating symptoms, tDCS aims to modulate brain activity, potentially altering the pain perception itself. Researchers are excited about this treatment because it has the potential to provide pain relief without the side effects commonly associated with medications, and it can be administered in short, daily sessions, offering a more convenient option for patients.

What evidence suggests that tDCS is effective for reducing chronic pain?

This trial will evaluate the effectiveness of transcranial direct current stimulation (tDCS) for chronic pain. Studies have shown that tDCS can significantly reduce chronic pain, with some individuals experiencing reductions of up to 40%. It has proven effective for conditions such as fibromyalgia, migraines, and nerve-related pain. Some research also suggests that combining tDCS with other treatments, like exercise, enhances results. Overall, tDCS appears to be a promising and non-invasive option for managing chronic pain. Participants in this trial will receive tDCS alongside an accelerated Behavioral Health Program to assess their combined effectiveness.15678

Who Is on the Research Team?

SR

Sheila Rauch, PhD

Principal Investigator

Emory University

Are You a Good Fit for This Trial?

This trial is for adults aged 18-89 with chronic pain who are part of the Emory Healthcare Veterans Program and have moderate to severe pain most days. Participants must be able to self-administer tDCS, have a primary care or pain provider, and not have certain medical conditions like seizures, brain surgery history, or use specific medications.

Inclusion Criteria

I am between 18 and 89 years old.
I am willing to use tDCS on myself and complete all required assessments.
Have an established PCP (Primary Care Provider) or pain management provider
See 2 more

Exclusion Criteria

I am currently taking Felbamate.
I have had brain surgery in the past.
I am currently taking sodium channel blocker medications.
See 26 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive short, daily tDCS treatment sessions for two weeks

2 weeks
10 sessions (in-person or virtual)

Follow-up

Participants are monitored for safety and effectiveness after treatment

12 months
Assessments at 3, 6, and 12 months post-intervention

What Are the Treatments Tested in This Trial?

Interventions

  • tDCS

Trial Overview

The study tests whether transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique, can help reduce chronic pain in veterans already enrolled in an accelerated behavioral health program. Pain levels will be measured using a standard questionnaire.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Transcranial Direct Current Stimulation (tDCS) plus accelerated Behavioral Health ProgramExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Emory University

Lead Sponsor

Trials
1,735
Recruited
2,605,000+

Citations

Effects of Transcranial Direct Current Stimulation on pain and ...

Our findings suggest that tDCS might be effective for fibromyalgia, migraine, and neuropathic pain associated with spinal cord injury and stroke ...

TRANSCRANIAL DIRECT CURRENT STIMULATION IS ...

Studies indicate that tDCS is a promising tool for the treatment of chronic pain13, 14, 15, 16. tDCS is a low-cost, painless, non-invasive, and ...

3.

pubmed.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov/39600390/

The effectiveness of home-based transcranial direct current ...

Low to moderate certainty evidence suggests that home-based self-administered tDCS is a safe and effective tool for managing various types of chronic pain.

Transcranial direct current stimulation combined with ...

Anodal tDCS combined with exercise provides a modest but significant additional reduction in pain intensity for CLBP. Longer intervention duration may enhance ...

(373) Evaluating outcomes of transcranial direct current ...

The baseline pain intensity (mean, SD) was 6.3 (2.5); after the 5th tDCS pain decreased by 41% to 3.7 (3.0), (p≤0.01). ... The tDCS procedure was well tolerated; ...

Effects of Direct Transcranial Current Stimulation on ...

Explore the effects of long-term tDCS on intrinsic connectivity between pain processing and modulatory regions and other brain networks (e.g. default mode ...

A meta-analysis of adverse effects associated with ...

The aim of this study was to assess tDCS safety in different chronic pain conditions. A systematic review and meta-analysis of 162 tDCS clinical trials was ...

8.

pubmed.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov/41099741/

A Systematic Review of Reporting Adverse Effects ...

In the present form of reporting AEs of tDCS in clinical studies involving patients with chronic pain, this procedure seems to be safe.