Acceptance and Commitment Therapy for Chronic Cough

(FAST-COUGH Trial)

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Overseen ByCarolyn K. Novaleski, Ph.D., CCC-SLP
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of North Carolina, Chapel Hill
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether Acceptance and Commitment Therapy (ACT), which includes breath control techniques, helps people with chronic cough. The goal is to determine if this therapy is feasible, safe, and well-received by participants. It targets individuals with a bothersome cough lasting at least eight weeks, who have ruled out common causes such as untreated lung, stomach, or sinus issues. Participants need internet access for virtual sessions and should be open to learning new ways to manage their cough. As an unphased trial, this study provides a unique opportunity to contribute to innovative research that could enhance chronic cough management.

Do I need to stop my current medications for the trial?

The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are currently using ACE inhibitor medications.

What prior data suggests that this therapy is safe for chronic cough?

Research has shown that Acceptance and Commitment Therapy (ACT) is generally safe for individuals with long-term health issues. Studies examining ACT for chronic diseases have found improvements in mindfulness and quality of life, with no major safety concerns reported.

One study focused on ACT for chronic airway diseases, such as chronic cough, and found no significant side effects. Participants tolerated the therapy well, indicating its safety.

Overall, while evidence suggests ACT is safe, individuals should consult their healthcare provider before starting any new treatment.12345

Why are researchers excited about this trial?

Unlike traditional treatments for chronic cough, which often rely on medications to suppress cough reflexes or treat underlying conditions, Acceptance and Commitment Therapy (ACT) focuses on psychological and behavioral techniques. ACT helps patients manage their coughing through mindfulness and acceptance strategies, combined with breath control techniques. Researchers are excited about this approach because it targets the psychological aspects of chronic cough, offering a potentially more holistic and sustainable way to manage symptoms without the side effects associated with medication.

What evidence suggests that Acceptance and Commitment Therapy is effective for chronic cough?

Research has shown that Acceptance and Commitment Therapy (ACT), which participants in this trial will receive, might improve symptoms in various long-term health conditions. ACT has enhanced quality of life and reduced symptoms. Studies indicate that ACT can assist in managing chronic pain, although researchers are still exploring its long-term effects. While data on chronic cough is limited, ACT's success with similar conditions suggests it could be helpful.23678

Who Is on the Research Team?

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Carolyn Novaleski, Ph.D., CCC-SLP

Principal Investigator

University of North Carolina, Chapel Hill

Are You a Good Fit for This Trial?

This trial is for adults aged 18-80 with a chronic cough lasting at least 8 weeks, who have seen certain specialists in the past year and have normal chest imaging. Participants must not be current smokers or taking ACE inhibitor medications, and should not have severe depression, anxiety, or distress.

Inclusion Criteria

Completed outpatient clinical encounter within the prior 12 months with a provider in pulmonary medicine, gastroenterology, otolaryngology, and/or allergy at UNC Health via medical chart review, with documentation that chronic cough (lasting 8 weeks or longer) was listed as one of the reasons for the visit, with terminology such as chronic, ongoing, recurrent, persistent, lingering, refractory, longstanding, constant, continual, continuous, prolonged, intermittent, frequent, repetitive, unresolved, non-resolving, habitual, troublesome, bothersome, unmanaged, unexplained, idiopathic, progressive, worsening, treatment-resistant, and/or intractable
I am between 18 and 80 years old.
Score ≤ 14 on the Patient Health Questionnaire-9 (PHQ-9), indicating no greater than moderate depressive symptom severity (maximum score: 27), via self-report using a screening questionnaire
See 9 more

Exclusion Criteria

Current smoking status via medical chart review
I am currently taking an ACE inhibitor medication.
Unable to read, understand, and speak English without an interpreter via medical chart review
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive brief, breath control-focused Acceptance and Commitment Therapy (ACT)

4 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Acceptance and Commitment Therapy (ACT)

Trial Overview

The study is testing if a brief program using Acceptance and Commitment Therapy (ACT) focused on breath control is practical, acceptable, and safe for adults with chronic cough. All participants receive the therapy over four weeks via videoconference.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Acceptance and Commitment Therapy (ACT)Experimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of North Carolina, Chapel Hill

Lead Sponsor

Trials
1,588
Recruited
4,364,000+

National Heart, Lung, and Blood Institute (NHLBI)

Collaborator

Trials
3,987
Recruited
47,860,000+

Citations

Efficacy of behavioral cough suppression therapy for refractory ...

The results showed a statistically significant improvement in LCQ scores among patients with chronic cough who underwent BCST, compared to those ...

Predictors of outcomes following interdisciplinary acceptance ...

This aim of this study was to investigate if baseline psychological flexibility (PF) profiles predict responses to an ACT‐based pain management programme.

Chronic Cough: Evaluation of Patients' Success in ...

In this observational study, the authors aim to identify the motivational factors that prompt patients' progression from the contemplation to action stage of ...

The Efficacy of Acceptance and Commitment Therapy for ...

Objectives: Previous meta-analyses of a small number of trials showed that acceptance and commitment therapy (ACT) might improve chronic pain.

Evaluation and Management Outcomes and Burdens in ... - PMC

BCST is safe, improves cough outcomes in up to 87% of patients, is inexpensive and efficient (i.e., patients typically need no more than four treatment sessions) ...

The Effects of an Acceptance and Commitment ... - PMC

This study aimed to preliminarily assess the effects of an interdisciplinary ACT-based treatment for chronic airway diseases by analyzing ...

A Systematic Review of the Use of Acceptance ...

Many have proposed that Acceptance and Commitment Therapy (ACT) may be particularly effective for improving outcomes in chronic ...

Acceptance and Commitment Therapy With and Without ...

This study will therefore examine whether ACT is more effective for chronic pain than an education program, and whether adding daily mindfulness training will ...