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Olive Oil for Heart Failure

(OLEA-HF Trial)

SC
SA
Overseen BySaiful Anuar Bin Singar, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Old Dominion University
Disqualifiers: Terminal illness, End-stage renal disease, Pregnancy, others
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The OLEA-HF study aims to explore whether daily supplementation of extra-virgin olive oil (EVOO) for 12 weeks during participation in a cardiac rehabilitation program (standard of care) is feasible in patients with heart failure with reduced ejection fraction (HFrEF). The investigators will also determine the effects of EVOO on functional capacity and quality of life.

Who Is on the Research Team?

SC

Salvatore Carbone, PhD, RDN

Principal Investigator

Macon & Joan Brock Virginia Health Sciences at Old Dominion University

Are You a Good Fit for This Trial?

This trial is for adults diagnosed with heart failure with reduced ejection fraction (a type of weakened heart muscle). Participants should be able to join a cardiac rehab program. Specific inclusion and exclusion details are not listed here.

Inclusion Criteria

I have heart failure with an ejection fraction of 35% or less.
I am enrolled in cardiac rehab at Sentara but have not started any sessions yet.
Able and willing to comply with study procedures and provide informed consent.

Exclusion Criteria

I am not able or willing to follow the dietary recommendations or use EVOO.
I have end-stage kidney disease.
I have uncontrolled fluid buildup in my body.
See 4 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive daily supplementation of extra-virgin olive oil (EVOO) for 12 weeks during participation in a cardiac rehabilitation program

12 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Trial Overview

The study tests if taking extra-virgin olive oil daily for 12 weeks, along with standard cardiac rehabilitation, helps people with this kind of heart failure. The main focus is on safety, feasibility, and effects on fitness and quality of life.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: Extra-virgin olive oilExperimental Treatment1 Intervention
Group II: Standard of careActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Old Dominion University

Lead Sponsor

Trials
25
Recruited
15,500+

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