Social Support for Liver Cancer

Not yet recruiting at 2 trial locations
KZ
Overseen ByKali Zhou
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Southern California
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how social resources like transportation, housing, and meal support can help people with liver cancer receive timely treatments. The goal is to determine if these resources can reduce delays and improve treatment outcomes. Participants will be divided into two groups: one will receive these social supports as part of a Social Determinants of Health Program, along with patient navigation, while the other will receive only patient navigation, which assists with scheduling and other logistical tasks. The trial seeks individuals diagnosed with liver cancer, who have limited insurance, and are planning to receive treatment. As an unphased trial, this study offers a unique opportunity to contribute to understanding how social support can enhance cancer care.

Do I have to stop taking my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It focuses on providing social support to reduce treatment delays for liver cancer patients.

What prior data suggests that these social support interventions are safe for liver cancer patients?

A previous study found that factors like transportation, housing, and meals are important for people with liver cancer. These factors can improve health outcomes without adding medical risks. Research has shown that meeting these social needs links to better survival rates and earlier diagnosis in liver cancer patients. Providing support such as transport, housing, or meals has no known physical side effects. Therefore, this kind of program is generally considered safe and well-tolerated.12345

Why are researchers excited about this trial?

Researchers are excited about the Social Determinants of Health (SDOH) Program for liver cancer because it offers comprehensive support beyond traditional medical treatments. Unlike standard options that mainly focus on chemotherapy, surgery, or radiation, this program addresses barriers to care by providing transportation through Lyft, housing support at Hyatt House LA, and meals from Project Angel Food LA. These services aim to reduce stress and improve overall well-being, potentially enhancing treatment outcomes by ensuring patients can consistently access their medical care. By targeting social and logistical challenges, the program hopes to improve quality of life and treatment adherence for liver cancer patients.

What evidence suggests that this trial's social support interventions could be effective for liver cancer?

Research has shown that social factors like transportation, housing, and meals significantly impact the health of liver cancer patients. This trial will compare two approaches: one group will receive a comprehensive program addressing social determinants of health (SDOH) with patient navigation, including transportation support through Lyft rideshares, housing support through Hyatt House LA - University Medical Center, and meal support through Project Angel Food LA. The other group will receive patient navigation only, which includes coordination of care and assistance with healthcare-related tasks. Studies have linked addressing these social factors to better survival rates and earlier detection of liver cancer. For instance, good access to healthcare and stable living conditions can lead to timely treatments and improved overall health. One study found that these social factors are connected to receiving curative treatments and reducing healthcare costs. Overall, addressing these social needs may help patients access necessary care promptly.13456

Are You a Good Fit for This Trial?

This trial is for adults with liver cancer (HCC, stages A-C) who are uninsured or have Medicaid. Participants must be able to give consent and plan to receive treatment. People with very advanced disease, other types of liver tumors, those unable to get treatment, pregnant or incarcerated individuals cannot join.

Inclusion Criteria

I am 18 years old or older.
Uninsured or underinsured (i.e., Medicaid as primary or secondary insurance)
Able to provide informed consent
See 1 more

Exclusion Criteria

My liver tumor is not hepatocellular carcinoma (HCC).
My liver disease is very advanced and my liver does not function well.
Incarcerated patients or pregnant patients
See 3 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Intervention

Participants receive social support interventions including transportation, housing, and meal support to improve treatment adherence

90 days
Frequent touchpoints with healthcare system

Follow-up

Participants are monitored for treatment uptake and health outcomes

2 years
Regular follow-up visits as per clinic schedule

Patient-reported outcomes assessment

Assessment of financial toxicity and quality of life using FACIT-COST and FACT-HEP surveys

6 months

What Are the Treatments Tested in This Trial?

Interventions

  • Patient Navigation
  • Social Determinants of Health Program

Trial Overview

The study tests if providing social support—like free rides to appointments, temporary housing help, and meal delivery—can help patients with liver cancer start and continue their treatments on time compared to usual care.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: SDOH and patient navigation programExperimental Treatment2 Interventions
Group II: Patient navigation onlyActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Southern California

Lead Sponsor

Trials
956
Recruited
1,609,000+

Citations

Impact of social determinants of health on hepatocellular ...

Race and social determinants of health were independently associated with curative treatment receipt and health care costs.

S1283 The Impact of Social Determinants of Health on...

Certain SDOH at diagnosis, namely gender, marital status, and surveillance were associated with improved overall survival and earlier HCC diagnosis.

Exploring social determinants and hepatocellular carcinoma

The review identified disparities in HCC outcomes linked to socioeconomic status, health care access, and racial and ethnic differences. Patients in ...

IMPACT OF SOCIAL DETERMINANTS OF HEALTH ON ...

This study investigates whether components of SDOH are associated with progression-free survival for HCC within Milan criteria and their effect on time to ...

Impact of SDOH on Hepatocellular Carcinoma

This study of over 32000 patients with HCC found that many people are not receiving these potentially life-saving screenings. Learn more.

6.

pubmed.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov/41579292/

Social determinants disadvantage score and liver health in the ...

Social determinants of health (SDOH) are crucial in shaping liver health outcomes, yet comprehensive assessments that span key SDOH domains are lacking.