High-Flavonoid Diet for Human Health
What You Need to Know Before You Apply
What is the purpose of this trial?
This randomized crossover study will compare low- and high-flavonoid diets in healthy adults to identify flavonoid-derived biomarkers in urine and plasma. Using targeted liquid chromatography-mass spectrometry (LC-MS) metabolomics, researchers will measure known and novel flavonoid metabolites and evaluate whether a higher flavonoid intake reduces carbonyl stress markers, including reactive carbonyl species (RCS) and advanced glycation end products (AGEs).
Who Is on the Research Team?
Shengmin Sang
Principal Investigator
North Carolina A&T State University Principal Investigator
Are You a Good Fit for This Trial?
This trial is for healthy adults. People with health conditions or on medications that could affect the study results may not be able to participate.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Wash-in Period
Participants complete a 2-week low-flavonoid wash-in period
Dietary Intervention
Participants consume either a high-flavonoid or low-flavonoid diet for 3 weeks, followed by a 3-week washout period, and then switch diets for another 3 weeks
Follow-up
Participants are monitored for changes in plasma and urine flavonoid metabolites and carbonyl stress biomarkers
What Are the Treatments Tested in This Trial?
Trial Overview
The study compares a diet high in flavonoids (compounds found in fruits and vegetables) to a low-flavonoid diet. Each participant tries both diets at different times, and researchers measure changes in certain markers related to stress in the body.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
All participants will first complete a 2-week low-flavonoid wash-in period. Participants in this sequence will then consume the low-flavonoid diet for 3 weeks, complete a 3-week low-flavonoid washout period, and then consume the high-flavonoid diet for 3 weeks.
All participants will first complete a 2-week low-flavonoid wash-in period. Participants in this sequence will then consume the high-flavonoid diet for 3 weeks, complete a 3-week low-flavonoid washout period, and then consume the low-flavonoid diet for 3 weeks.
Find a Clinic Near You
Who Is Running the Clinical Trial?
North Carolina Agriculture & Technical State University
Lead Sponsor
National Institutes of Health (NIH)
Collaborator
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.