Pulsed Electric Field Ablation for Breast Cancer

This trial tests a new approach called Pulsed Electric Field (PEF) Ablation to treat specific breast cancer spots that have spread near the skin. The researchers aim to determine if this method is safe for individuals with metastatic breast cancer, where the cancer has spread from its original site. Individuals with confirmed breast cancer that has spread to or just below the skin and is clearly visible on imaging may be suitable candidates.

As an unphased trial, this study provides patients the opportunity to contribute to pioneering research that could lead to new treatment options.

Yes, you will need to stop your systemic therapy for breast cancer one week before the procedure and for 2 weeks after it. Additionally, you must be able to withhold anticoagulation or antiplatelet therapy as per guidelines.

Research has shown that pulsed electric field (PEF) ablation is generally safe for treating cancer. Previous studies have found PEF to be a minimally invasive and effective treatment, particularly beneficial when breast cancer becomes resistant to other therapies.

In one study, PEF treatment was successfully delivered before surgery every time, achieving a 100% technical success rate. Another study confirmed its safety but noted the need for more research with larger groups to validate these findings.

A specific case report described a long-lasting positive response in breast cancer following PEF ablation, suggesting enduring effects. Importantly, PEF treatment maintained a good safety record, with no significant side effects directly related to the treatment.

Unlike the standard treatments for metastatic breast cancer, such as chemotherapy, radiation, and surgery, Pulsed Electric Field (PEF) Ablation represents a novel approach. PEF Ablation uses electrical pulses to target and destroy cancerous cells without damaging surrounding healthy tissue. This targeted method reduces collateral damage and could potentially lead to fewer side effects, which is why researchers are excited about its potential. Moreover, the treatment is delivered in a single session, which could offer a more convenient option for patients compared to the often lengthy cycles of chemotherapy or radiation therapy.

Research has shown that pulsed electric field (PEF) ablation can shrink or destroy tumors by delivering short bursts of electrical energy. In studies with mice, PEF not only slowed breast cancer growth but also enhanced the immune system's ability to combat the cancer. A case report demonstrated that a patient with advanced breast cancer experienced a lasting positive response to PEF treatment. Compared to radiofrequency (RF) ablation, PEF improved the body's ability to recognize and fight specific cancer cells. Early findings suggest that PEF holds promise for treating breast cancer by both targeting tumors and boosting the immune system. Participants in this trial will receive a single PEF ablation treatment applied to up to three soft tissue metastatic breast cancer lesions.¹³⁶⁷⁸