Cognitive Training for Brain Cancer

EJ
Overseen ByEmily J Amsden, BS
Age: < 65
Sex: Any
Trial Phase: Academic
Sponsor: Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether an online cognitive training program can help children with brain tumors improve their thinking speed. The researchers aim to determine if the program is easy to use during and after cancer treatment and if both children and their caregivers find it well-received. Participants will complete short online exercises and check in with a coach over eight weeks. Children diagnosed with a brain tumor within the last five years and receiving care at Johns Hopkins Hospital may be suitable for this study. As an unphased trial, this study offers participants a unique opportunity to contribute to innovative research that could enhance cognitive recovery for children with brain tumors.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that this cognitive training intervention is safe for children with brain tumors?

Research shows that online brain training exercises are generally safe and easy to manage. Studies have found that these exercises can enhance mental skills like attention and processing speed without causing major side effects. For instance, one study found that children with cancer who participated in these exercises improved their memory and attention. Another study showed that cancer survivors experienced better thinking skills and reported a higher quality of life after using similar programs.

The absence of serious problems in these studies suggests that this training is safe for participants. This is not a new medication but a type of mental workout, which typically carries very low risks. Overall, current evidence supports that this training is safe and may help improve thinking skills in children with brain tumors.12345

Why are researchers excited about this trial?

Unlike the standard treatments for brain cancer, which often include surgery, radiation, and chemotherapy, this cognitive intervention is a non-invasive, online program. Researchers are excited about this treatment because it focuses on enhancing processing speed, a crucial cognitive function often affected by brain cancer and its treatments. This digital approach allows for easy access and flexibility, potentially improving patients' quality of life without the side effects associated with traditional therapies.

What evidence suggests that this cognitive intervention is effective for improving processing speed in children with brain tumors?

Research has shown that online brain training can help children with brain tumors enhance their thinking skills. One study found that using an iPad for brain exercises helped these children think more clearly and manage daily tasks better. Another study demonstrated improvements in overall cognitive abilities and task management skills. Evidence also suggests that this training can improve attention and quality of life. These findings support the potential of the computerized cognitive training intervention being tested in this trial to enhance mental health outcomes in young patients with brain tumors.23467

Who Is on the Research Team?

RK

Rachel K Peterson, PhD

Principal Investigator

Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

Are You a Good Fit for This Trial?

This trial is for children and young adults (up to age 25) who have a primary brain tumor, were diagnosed within the past five years, and are receiving care at Johns Hopkins Hospital.

Inclusion Criteria

My main tumor is located in my brain.
I was diagnosed with my condition at age 25 or younger.
4. Receiving care at Johns Hopkins Hospital
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Cognitive Intervention

Participants complete 15 minutes of online computerized cognitive training 5 times a week for 8 weeks, with weekly check-ins with the cognitive coach

8 weeks
Weekly check-ins (virtual)

Post-Intervention Assessment

Participants fill out acceptability surveys and complete post-neuropsychological testing

1 week

Follow-up

Participants are monitored for changes in processing speed 6 months after intervention completion

6 months

What Are the Treatments Tested in This Trial?

Interventions

  • Online computerized cognitive training intervention

Trial Overview

The study tests an online cognitive training program aimed at improving thinking speed. Participants do short daily exercises for eight weeks, with weekly check-ins and before-and-after testing. There is no comparison group.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Cognitive InterventionExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

Lead Sponsor

Trials
93
Recruited
25,200+

Citations

Effectiveness of a Computerized Home-Based Cognitive ...

Cognitive, physical, and emotional improvements were observed, along with decreased interference in daily life activities and a better overall quality of life.

Web-based cognitive interventions on subjective ...

This review demonstrated that web-based cognitive interventions optimized SCI and overall psychosocial and emotional statuses for the cancer survivors.

Remotely supervised online cognitive training to reduce ...

Cognitive training is considered as one of the most effective approaches for improving cognitive function in patients with CRCI. As implementing ...

Computerized cognitive training improves ...

In this prospective pilot study, web-based cognitive training was efficacious in improving overall cognitive performance and executive function.

Computer-Based Cognitive Training in Children with ...

In this systematic review, we analyse the current evidence and trends regarding computer-based cognitive rehabilitation in paediatric patients diagnosed with, ...

Computer-Based Cognitive Training in Children with ... - PMC

Conclusions: The studies suggest that this type of intervention improves cognitive functions, such as working memory, attention, and processing speed. However, ...

Efficacy of Technology-Based Cognitive Rehabilitation ...

The results revealed significant improvements in perceived cognition and in cognitive performance on speed-of-processing tests immediately after the digital ...