20 Participants NeededMy employer runs this trial

Fixation Training for Photophobia After Head Injury

AH
Overseen ByAndrew Hartwick, OD, PhD
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests whether exposure to colored lights can reduce light sensitivity after a head injury. Participants will use a device at home, focusing on either a blue or red light for 20 minutes daily. The study will compare changes in light sensitivity and pupil reactions to determine if blue light is more effective than red light. Individuals with mild or moderate head injuries who experience increased light sensitivity may consider joining.

As an unphased trial, this study allows participants to contribute to innovative research that could lead to new treatments for light sensitivity.

Will I have to stop taking my current medications?

If you are currently taking cholinergic medications (which affect pupil responses), you will need to stop taking them to participate in this trial.

What prior data suggests that this fixation training is safe for individuals with light sensitivity after head injury?

Research shows that using colored lights for eye training is generally safe. Studies on similar treatments have not reported any serious side effects. Many eye doctors already use this method for patients sensitive to light after a head injury, indicating it is well-tolerated.

This trial tests two colors of light: blue and red. These colors are commonly used in medical settings, and previous studies have not reported any major problems with them. While the effectiveness of this treatment is still under study, the available safety information is reassuring.

Overall, existing research provides confidence that using colored lights for eye training is a safe option for people with light sensitivity after a head injury.12345

Why are researchers excited about this trial?

Researchers are excited about fixation training for photophobia after head injury because it offers a new, non-invasive method to manage light sensitivity, which is a common issue following head trauma. Unlike standard treatments that often involve medications or lifestyle changes to minimize exposure to light, this approach uses colored light targets to potentially retrain the eyes and brain. The trial explores two sequences of colored light exposure—red light first followed by blue light, and vice versa—to determine if such visual exercises can reduce photophobia symptoms. This could pave the way for a more targeted, drug-free treatment option for those affected by head injuries.

What evidence suggests that this trial's fixation training using different colored light targets could be effective for photophobia after head injury?

Research has shown that using colored lights for eye exercises might help with light sensitivity after a head injury. In this trial, participants will undergo fixation training with different colored fixation targets. One group will start with red light followed by blue light, while another group will start with blue light followed by red light. Many doctors have observed that patients feel better after daily exercises with a dim light, especially blue light. This involves focusing on a light, which can help reduce light sensitivity. Although a detailed study has not yet proven its effectiveness, eye care professionals have shared positive feedback, suggesting this method might reduce discomfort caused by bright lights.12678

Are You a Good Fit for This Trial?

This trial is for people who have recently had a head injury and now experience increased sensitivity to light (photophobia).

Inclusion Criteria

Completion of first session in entirety (participants who cannot complete the entire first visit will be considered as a screen fail)
I am between 18 and 80 years old and can give my own consent.
My vision is at least 20/32 in each eye and 20/25 with both eyes together.
See 1 more

Exclusion Criteria

Prior participation in fixation training sessions within the past 2 years
Pregnancy or suspected pregnancy based on self-report
Prior history of severe TBI (score of 5 or 6 on OSU-TBI survey)
See 4 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment Phase 1

Participants undergo daily 20-minute fixation training sessions using a blue or red light target for 12 weeks

12 weeks
Visits every 6 weeks for assessments

Treatment Phase 2

Participants switch to the other colored light target for another 12 weeks of daily 20-minute fixation training sessions

12 weeks
Visits every 6 weeks for assessments

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Fixation training using different colored fixation targets

Trial Overview

The study compares daily at-home eye fixation training using either a blue or red colored light target. Each participant tries both colors in separate 12-week periods, with regular vision and symptom checks.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Group I: Red light first, blue light secondExperimental Treatment1 Intervention
Group II: Blue light first, red light secondExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Ohio State University

Lead Sponsor

Trials
891
Recruited
2,659,000+

Ohio Lions Eye Research Fund

Collaborator

Citations

Effect of Fixation Training With Colored Light Targets ...

In short, this study will compare the effect of fixation training using a blue light target to the effect of fixation training using a red light ...

Traumatic brain injury: Mechanisms, manifestations, and ...

Abstract. Traumatic brain injury (TBI) results when external physical forces impact the head with sufficient intensity to cause damage to the brain.

Light Sensitivity After Head Injury: 5 Effective Treatments

Light sensitivity, or photophobia, is one of the most common symptoms of mild traumatic brain injury and concussion.

Consensus Statement on Visual Rehabilitation in Mild ...

Correlation of diplopia with afferent TBI symptoms such as photophobia, blurred vision, and difficulty reading has not been demonstrated, and afferent symptoms and ...

Photophobia, Light Sensitivity after Traumatic Brain Injury ...

To top it all off, a relative split of concussion patients experienced a reduction in photophobia (50%) over the years while a similar ...

Light Sensitivity After Head Injury: 5 Effective Treatments

Light sensitivity, or photophobia, is one of the most common symptoms of mild traumatic brain injury and concussion.

TBI in the Workplace Facts | Traumatic Brain Injury & ...

Some jobs may have higher risk for Traumatic Brain Injury, including construction workers, professional drivers, emergency responders, minders, warehouse ...

best-practices-guidelines-traumatic-brain-injury. ...

The aim is to present a comprehensive but practical guide for the management of patients with TBI. Best practices can improve standards of care as well as ...