Psychotherapy for PTSD and Traumatic Brain Injury
(T3 for PTSD Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a special therapy designed to help military veterans and active service members with PTSD (posttraumatic stress disorder) and mild traumatic brain injuries (mTBI). The treatment involves individual therapy sessions focused on managing PTSD symptoms. It suits those diagnosed with mTBI, experiencing PTSD symptoms, and who haven't recently changed medications. The trial aims to improve mental health and quality of life for those affected. As an unphased trial, it offers participants a unique opportunity to contribute to valuable research that could enhance treatment options for PTSD and mTBI.
Will I have to stop taking my current medications?
The trial requires that participants be stable on their medications, meaning you should not have any changes in your medication prescriptions in the 4 weeks before starting the trial.
What prior data suggests that this psychotherapy treatment is safe for military veterans and service members with mTBI and PTSD?
Research has shown that individual talk therapy for PTSD in people with mild traumatic brain injury (mTBI) can be safe and helpful. Participants, regardless of a history of TBI, demonstrated significant improvements in PTSD and depression symptoms during therapy. This indicates that talk therapy is well-tolerated and effective for these conditions.
Although specific safety data for this exact treatment is lacking, the focus on non-invasive talk therapy is promising. Talk therapy typically avoids the physical side effects that medications might cause. However, individuals may still experience some emotional discomfort as they work through their experiences. Overall, this type of therapy is generally considered safe for treating PTSD and mTBI.12345Why are researchers excited about this trial?
Researchers are excited about this treatment because it takes a novel approach to addressing mild Traumatic Brain Injury (mTBI) and PTSD. Unlike traditional treatments that often focus on trauma-specific therapies or medications, this non-trauma-focused psychotherapy provides an alternative by potentially offering relief without revisiting traumatic events. This approach could be especially appealing for patients who find trauma-focused therapy daunting or emotionally taxing. Additionally, the treatment is specifically tailored for active duty service members and veterans, addressing their unique needs and experiences, which makes it a promising option for this specific population.
What evidence suggests that this treatment might be an effective treatment for PTSD and TBI?
Research has shown that therapy can effectively reduce PTSD symptoms, even for people with mild traumatic brain injury (mTBI). Studies have found that therapy helps manage PTSD symptoms, regardless of a history of mTBI. Early results suggest that people with mTBI can still benefit from PTSD treatments. Participating in cognitive rehabilitation, a component of therapy, may improve emotional control and daily life skills. Overall, this treatment offers hope for those dealing with both PTSD and mTBI.36789
Who Is on the Research Team?
Cindy McGeary, PhD
Principal Investigator
The University of Texas Health Science Center at San Antonio
Are You a Good Fit for This Trial?
This trial is for military veterans and service members who have mild traumatic brain injuries (TBI) along with PTSD. Specific eligibility criteria are not provided, but typically participants would need to meet diagnostic criteria for both conditions.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive individual psychotherapy sessions to manage PTSD
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Non-Trauma Treatment for mTBI and PTSD
Trial Overview
The study is testing a specialized psychotherapy treatment tailored for individuals with both mild TBI and PTSD. The therapy involves individual sessions aimed at managing the symptoms of PTSD in this specific population.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Male and female active duty service members and veterans at least 18 years of age who are seeking clinical care for mild Traumatic Brain Injury (TBI) symptoms at the Intrepid Spirit Center located on Fort Hood who also have a co-occurring diagnosis of PTSD
Find a Clinic Near You
Who Is Running the Clinical Trial?
The University of Texas Health Science Center at San Antonio
Lead Sponsor
United States Department of Defense
Collaborator
Citations
Non-Trauma Intervention to Treat PTSD for Veterans and ...
The objective of this study is to test a non-trauma intervention for PTSD tailored to military veterans and service members with mTBI called ...
Effectiveness of Psychotherapy for Post-Traumatic Stress ...
Results: Both psychotherapies were equally effective in reducing PTSD symptoms, regardless of TBI status. The early initiation of treatment ...
3.
health.mil
health.mil/Reference-Center/Publications/2026/01/20/TBICoE-Research-Review-Mild-TBI-and-PTSDResearch Review on PTSD and TBI
Engaging in cognitive rehabilitation may also have a positive impact on other outcomes including emotional regulation and functional performance ...
Mild traumatic brain injury characteristics do not negatively ...
However, research suggests that those with a history of mTBI can benefit from evidence-based PTSD treatment. To extend these findings, we examined whether ...
Outcomes in Patients With Mild Traumatic Brain Injury ...
This study found that most participants with a GCS score of 15 and negative head CT scan reported incomplete recovery at 2 weeks and 6 months after their ...
The Influence of Traumatic Brain Injury on Treatment ...
Participants with and without TBI history demonstrated significant improvements in PTSD and depression symptoms during the course of treatment. However, ...
7.
health.mil
health.mil/Reference-Center/Publications/2023/09/29/TBICoE-Research-Review-Mild-TBI-and-PTSDResearch Review on Mild Traumatic Brain Injury and Post- ...
The purpose of this research review is to provide an overview of the topic of comorbid mild traumatic brain injury and posttraumatic stress ...
Genetic vulnerability and adverse mental health outcomes ...
A prospective cohort study of civilians who sustained traumatic injuries found that individuals with mTBI were more likely to develop PTSD, with an odds ratio ...
NCT03796936 | 3MDR to Treat PTSD With mTBI (3MDR)
There is no proven treatment for mTBI, and standard treatments for PTSD frequently achieve only transient, modest impact. Motion-assisted, Multi-modular Memory ...
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.