Overnight Cooling for Heat Exposure
What You Need to Know Before You Apply
What is the purpose of this trial?
Extreme heat events are becoming more frequent, intense, and prolonged, increasing the risk of heat-related illness among workers exposed to hot environments. Current occupational heat-stress guidelines are designed to limit excessive increases in core body temperature and physiological strain during work in the heat through the use of work-rest schedules. However, these guidelines are largely based on single-day heat exposures and assume that workers recover in cool indoor environments between shifts. During heat events, many workers may instead recover in homes or accommodations that remain overheated, particularly in the absence of air conditioning. Inadequate overnight cooling may impair the body's ability to dissipate heat, increase physiological strain, and reduce tolerance to heat exposure on subsequent workdays. Older adults may be especially vulnerable due to age-related impairments in heat-loss capacity. To date, the effects of recovering in an overheated indoor environment on physiological strain and thermoregulatory function during repeated occupational heat exposure remain poorly understood, limiting the development of evidence-based recommendations to protect workers during prolonged heat events.
The primary objective of this study is to determine whether overnight recovery in an overheated indoor environment increases physiological strain during repeated occupational heat exposure in older adults. Specifically, investigators will assess whether recovery at the recently proposed upper indoor temperature limit of 26°C and 45% relative humidity (RH) (PMID: 38329752) is sufficient to attenuate elevations in core temperature during subsequent work in the heat compared with recovery in an overheated indoor environment (31°C, 45% RH) representative of conditions commonly experienced during extreme heat events. Healthy older adults will complete two consecutive days and nights of simulated moderate-intensity occupational heat exposure, with overnight recovery occurring in either the 26°C or 31°C condition. Measures of core temperature, cardiovascular strain, heat-loss capacity, hydration status, sleep quality, cognitive function, mood, and perceptual responses will be assessed to determine the impact of overnight recovery conditions on responses to repeated heat exposure. Whole-body heat-loss capacity will also be evaluated before and after the exposure protocol as assessed during incremental, intermittent exercise protocol performed in an air calorimeter.
Are You a Good Fit for This Trial?
This trial is for healthy, physically active men who are English or French speaking, do not smoke (or quit over 5 years ago), and can give consent. They should not have serious health issues like uncontrolled high blood pressure, heart problems, severe diabetes complications, or be regularly exposed to hot environments at work.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants complete a 2-day, 2-night simulated occupational heat exposure protocol with overnight recovery in different temperature conditions
Follow-up
Participants are monitored for physiological responses and recovery post-exposure
What Are the Treatments Tested in This Trial?
Trial Overview
The study compares how recovering overnight in a cool room (26°C) versus an overheated room (31°C) affects older adults' ability to handle repeated days of working in heat. Participants will experience both conditions on separate occasions while researchers monitor their body temperature and other health measures.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Participants complete a 2-day, 2-night simulated occupational heat exposure protocol consisting of daytime work in a hot environment (37.5°C, 35% RH) and overnight recovery (18:30-08:00) in an overheated indoor environment (31°C, 45% RH).
Participants complete a 2-day, 2-night simulated occupational heat exposure protocol consisting of daytime work in a hot environment (37.5°C, 35% RH) and overnight recovery (18:30-08:00) at the recommended upper indoor temperature limit (26°C, 45% RH).
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Who Is Running the Clinical Trial?
University of Ottawa
Lead Sponsor
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