50 Participants NeededMy employer runs this trial

Sleep Pattern Changes for ADHD

(AACT Trial)

DB
SB
Overseen ByStephen Becker, Ph.D.
Age: < 18
Sex: Any
Trial Phase: Academic
Sponsor: Children's Hospital Medical Center, Cincinnati
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how changes in sleep patterns affect adolescents with ADHD, focusing on their attention and overall functioning. Participants will adjust their sleep schedules over three weeks to assess the impact of both sleep duration and timing. The trial includes two sleep conditions: one where sleep aligns with their natural tendencies (aligned sleep extension) and another where it does not (misaligned sleep extension). Teens diagnosed with ADHD who typically go to bed late or wake up early might be suitable candidates. The research aims to determine if the timing of sleep is as important as the amount of sleep. As an unphased trial, this study offers participants the chance to contribute to groundbreaking research on sleep and ADHD.

What prior data suggests that these sleep pattern changes are safe for adolescents with ADHD?

Research has shown that more sleep can benefit children with ADHD. One study found that increasing sleep improved impulse control by 13%. This suggests that adequate sleep might help manage ADHD symptoms.

When sleep times align with a child's natural sleep pattern, known as aligned sleep extension, children with ADHD tend to sleep better. More children became good sleepers after increasing their sleep, indicating that this approach is well-received.

Conversely, if sleep times do not align with natural patterns, called misaligned sleep extension, ADHD symptoms like inattention and emotional issues can worsen. However, extending sleep is considered safe, primarily affecting symptom management rather than causing harm.

Overall, these sleep changes are safe and might help manage ADHD symptoms, though their effectiveness depends on how well the sleep schedule fits a child's natural sleep rhythm.12345

Why are researchers excited about this trial?

Researchers are excited about these sleep pattern changes for ADHD because they explore how aligning or misaligning sleep schedules with an adolescent's natural body clock could impact ADHD symptoms. Unlike standard ADHD treatments that often involve medication like stimulants or behavioral therapy, this approach focuses on optimizing sleep duration and timing. By allowing 9.5 hours of sleep tailored to fit or deliberately misalign with an individual's natural sleep preference, researchers hope to uncover new insights into how sleep affects ADHD, potentially offering a non-pharmacological way to manage symptoms.

What evidence suggests that this trial's sleep pattern changes could be effective for ADHD?

This trial will compare two sleep extension strategies for teenagers with ADHD: Aligned Sleep Extension and Misaligned Sleep Extension. Research has shown that more sleep can improve symptoms in teenagers with ADHD. In one study, children with ADHD who increased their sleep improved their ability to control impulsive actions by 13%, meaning they were better at stopping themselves from acting without thinking. Conversely, sleep that doesn't align with a person's natural sleep-wake cycle can worsen attention and behavior problems. Studies have found that sleep issues are linked to increased difficulties with attention and rule-following. Overall, getting enough sleep at the right times appears to help manage ADHD symptoms more effectively.26789

Who Is on the Research Team?

DB

Dean Beebe, Ph.D.

Principal Investigator

Children's Hospital Medical Center, Cincinnati

SB

Stephen Becker, Ph.D.

Principal Investigator

Children's Hospital Medical Center, Cincinnati

Are You a Good Fit for This Trial?

This trial is for healthy adolescents aged 13-17 who have been diagnosed with ADHD. Participants should not have other major health issues and must be able to follow different sleep schedules over three weeks.

Inclusion Criteria

I have been diagnosed with ADHD inattentive or combined type after a clinical interview.
I am between 13 and 17 years old.

Exclusion Criteria

Non-traditional school setting (morning-afternoon Monday-Friday)
I do not take melatonin or stimulant medications, or I am willing to stop them for 3 weeks.
I am not able or willing to follow the study's procedures.
See 5 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Baseline Sleep Schedule

Participants follow a sleep schedule that fits their usual non-obligatory schedule

1 week
1 evening session (in-person)

Short Sleep Condition

Participants sleep for 6.5 hours per night to assess the impact of reduced sleep

1 week
1 evening session (in-person)

Sleep Extension Condition

Participants sleep for 9.5 hours per night with timing aligned or misaligned with their chronotype

1 week
1 evening session (in-person)

Follow-up

Participants are monitored for changes in attention and emotional regulation

1-2 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Aligned sleep extension
  • Misaligned sleep extension

Trial Overview

The study tests how changing both the amount and timing of sleep affects attention, mood, and thinking in teens with ADHD. Participants try out short sleep, well-timed longer sleep, or poorly timed longer sleep across separate weeks.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Group I: Misaligned Sleep ExtensionExperimental Treatment1 Intervention
Group II: Aligned Sleep ExtensionExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Children's Hospital Medical Center, Cincinnati

Lead Sponsor

Trials
844
Recruited
6,566,000+

National Institute of Mental Health (NIMH)

Collaborator

Trials
3,007
Recruited
2,852,000+

Citations

1.

pubmed.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov/36603513/

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