Enamel Matrix Derivative for Gum Health
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests whether a treatment called Enamel Matrix Derivative (EMD) can promote thicker gum tissue growth around dental implants. Researchers believe EMD can enhance gum health and are evaluating its effectiveness with implants. Participants will either receive this treatment during implant procedures or not, to compare results. Suitable candidates have dental implants ready for a second stage of uncovering and can attend all study visits. As an unphased trial, this study offers participants the chance to contribute to groundbreaking research that could improve dental implant outcomes.
Do I need to stop my current medications for the trial?
The trial does not specify if you need to stop taking your current medications, but it does exclude patients who are on anticoagulants (blood thinners).
What prior data suggests that using Enamel Matrix Protein is safe for gum health?
Research has shown that enamel matrix derivatives (EMD) are generally safe for dental procedures. Since 1996, EMD has been used in gum treatments and is approved by the FDA for these purposes. Studies have found that it aids in healing and tissue growth around teeth.
Both animal and human studies support EMD's safety. These studies indicate that EMD promotes gum tissue growth and healing without causing major side effects. Although more research is needed to fully understand its effectiveness, current evidence suggests that EMD is safe and well-tolerated for improving gum health.12345Why are researchers excited about this trial?
Unlike the standard of care for gum health, which often involves cleaning and surgery to remove infected tissue, the enamel matrix derivative (EMD) treatment is derived from enamel matrix proteins that play a key role in tooth development. This treatment is unique because it uses these proteins to stimulate the regeneration of gum tissue and bone, potentially promoting natural healing and repair. Researchers are excited about EMD because it targets the underlying problem by encouraging the body’s own regenerative processes, which could lead to healthier gums without the need for more invasive procedures.
What evidence suggests that Enamel Matrix Protein is effective for improving gum health around implants?
This trial will compare the use of Enamel Matrix Derivative (EMD) with no intervention for gum health. Studies have shown that EMD effectively aids in the healing of gums and bones. Research indicates that EMD can thicken gums around teeth, benefiting overall gum health. Clinical studies have demonstrated positive results in tissue healing with EMD, particularly for bone loss and gum disease. EMD supports the healing process and helps maintain healthier gums, making it a promising option for improving gum health around dental implants.13467
Who Is on the Research Team?
Angela Palaiologou-Gallis, DDS
Principal Investigator
The University of Texas Health Science Center at San Antonio
Are You a Good Fit for This Trial?
This trial is for adults aged 18-89 who need dental implant uncovering and can consent to the study. They must speak English, not be pregnant or planning pregnancy, have no allergies to EMD, not object to animal products, and not be on blood thinners.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
EMD is deposited under the mucosal flap during the second stage implant uncovering
Follow-up
Participants are monitored for mucosal thickness and keratinized mucosal width at one and three months
What Are the Treatments Tested in This Trial?
Interventions
- Enamel Matrix Protein
Find a Clinic Near You
Who Is Running the Clinical Trial?
The University of Texas Health Science Center at San Antonio
Lead Sponsor