Implementation Intervention for Alcoholism and Alcoholic Liver Disease
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to improve treatment for people with alcohol use disorder (AUD) and alcohol-associated liver disease (ALD) by integrating medications with brief counseling. It focuses on enhancing care in hepatology clinics to reduce liver-related complications. The trial educates clinicians in these clinics to better support patients with AUD and ALD through an implementation intervention. It suits healthcare professionals who work directly with liver disease patients in the specified medical system. As an unphased trial, this study allows patients to contribute to innovative care strategies that could significantly improve treatment outcomes.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that this implementation intervention is safe?
Research has shown that treatments for alcohol use disorder, particularly when combined with counseling, can be safe for individuals with alcohol-related liver disease. Previous studies found that these treatments are generally well-tolerated. For instance, combining medication with counseling can reduce liver problems without major side effects.
Although specific data on this particular approach is not available, it emphasizes education and support rather than new drugs or risky procedures, suggesting a low risk for participants. Safety remains a priority, with the process involving education for both doctors and patients, ensuring careful monitoring and support throughout.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it introduces a comprehensive approach to treating alcoholism and alcoholic liver disease. Unlike standard treatments that typically focus solely on medication or counseling, this intervention combines clinician and patient education, clinical decision support, and feedback for healthcare providers. By focusing on educating hepatology clinicians and providing them with tools and feedback, the trial aims to enhance the overall quality of care and improve patient outcomes. This multi-faceted strategy has the potential to address gaps in current treatment methods and provide a more holistic approach to managing these conditions.
What evidence suggests that this implementation intervention is effective for alcohol use disorder and alcohol-associated liver disease?
Studies have shown that treating alcohol use disorder (AUD) can significantly reduce liver problems. For example, one study found that both therapy and medication for AUD improved liver function. Another study demonstrated that stopping alcohol use after an alcohol-related liver disease (ALD) diagnosis increased life expectancy and decreased liver issues. Additionally, combining treatments like counseling and support from healthcare providers effectively reduced alcohol use and improved liver health in people with liver disease. These findings suggest that a combined approach to treating AUD and ALD can be very beneficial.
In this trial, hepatology clinicians will engage in a multipronged intervention, including clinician education, patient education, clinical decision support, and clinician audit and feedback, to test its effectiveness in improving outcomes for patients with AUD and ALD.56789Who Is on the Research Team?
Lamia Haque
Principal Investigator
Yale University
Are You a Good Fit for This Trial?
This trial is for healthcare providers who care for patients with liver disease at hepatology clinics within the Yale School of Medicine and YNHH medical system.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Intervention
Hepatology clinicians participate in educational sessions and implementation facilitation intervention
Follow-up
Participants are monitored for the feasibility and acceptability of the intervention
What Are the Treatments Tested in This Trial?
Interventions
- Implementation Intervention
Trial Overview
The study is testing a program to help doctors offer medications and brief counseling for alcohol use disorder in people with alcohol-related liver disease, aiming to improve how this care is delivered in liver clinics.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Clinician participants will participate in a multipronged intervention including hepatology clinician education, patient education, clinical decision support, and clinician audit and feedback which will be adapted and tested. Participants will attend two approximately 60-minute-long educational sessions in which key points related to AUD treatment based on the HPCR resource and implementation facilitation intervention will be reviewed.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Yale University
Lead Sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Collaborator
Citations
Impact of Alcohol Use Disorder Treatment on Clinical ... - PMC
In adjusted analyses, behavioral and/or pharmacotherapy-based AUD treatment was associated with a significant reduction in incident hepatic decompensation (6.5% ...
The effectiveness of web-based interventions on non ...
This study aims to carry out a web-based continuum of a care intervention model to provide comprehensive care interventions for obese children with NAFLD.
Implementation of Mobile-based Programs for Alcohol ...
The hypothesis is that the implementation of an adapted version of Connections for patients with ALD will improve rates of alcohol cessation and improve liver ...
Designing clinical trials to address alcohol use and ...
Although abstinence from alcohol after diagnosis of ALD improves life expectancy and reduces the risk of decompensation of liver disease, few ...
Efficacy of Psychosocial Interventions in Inducing and ...
In this study, the investigators randomized 61 patients with alcoholic cirrhosis or symptomatic alcoholic hepatitis and severe alcohol abuse ...
EASL Clinical Practice Guidelines: Management of alcohol ...
Alcoholic steatohepatitis is considered a progressive lesion, which increases the risk of cirrhosis and HCC. The principal morphological features of ASH include ...
Inpatient Screening, Brief Intervention, and Referral to ...
“Epidemiology of Alcohol Consumption and Societal Burden of Alcoholism and Alcoholic Liver Disease.” ... Outcomes for Alcoholic Hepatitis: A ...
Treatment of alcohol use disorder in patients with liver ...
One such treatment is the approach avoidance training program, in which patients are requested to respond with avoidance to pictures of alcoholic drinks (by ...
Designing clinical trials to address alcohol use and ... - PMC
In the USA, a report from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) showed that 52% of cirrhosis-related deaths in 2019 were attributable ...
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