Peer Support for Alcoholic Liver Disease

(THRIVES Trial)

ME
PC
Overseen ByPo-Hung Chen, MD, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Johns Hopkins University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests whether working with peer support specialists (PSS) benefits individuals who have undergone a liver transplant for alcohol-related liver disease. It seeks to determine if these patients are less likely to resume drinking and if they adhere better to their medical care plans, potentially improving overall recovery. The trial targets English speakers who have had a liver transplant due to alcohol-related liver disease and have abstained from alcohol for 1 to 3 years. The goal is to discover if peer support can significantly impact their health and recovery journey. As an unphased trial, this study allows participants to contribute to innovative research that could enhance recovery support for others in similar situations.

Do I need to stop my current medications to join the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that peer support is safe for liver transplant recipients with alcohol-related liver disease?

Studies have shown that peer support can safely and effectively improve care for people with alcohol-related liver disease. Research indicates that adding peer support to medical treatment can address gaps in mental and emotional support. Since this type of support doesn't involve medication, it usually avoids side effects associated with drugs.

One study found that participants handled peer support easily, experiencing no harm or unpleasant effects. This suggests it is a well-accepted approach for those recovering from liver transplants due to alcohol-related liver disease. Overall, peer support is considered a safe option to aid recovery and enhance quality of life.12345

Why are researchers excited about this trial?

Researchers are excited about the peer support approach for alcoholic liver disease because it offers a unique way to tackle the condition beyond traditional medical treatments. Unlike standard care, which often focuses on medication and lifestyle changes, peer support leverages the power of shared experiences and social connection. This method aims to provide emotional and motivational support from individuals who have faced similar challenges, potentially leading to improved adherence to treatment plans and sustained behavioral changes. This innovative approach could complement existing treatments, making it an exciting area of exploration for researchers.

What evidence suggests that peer support is effective for alcoholic liver disease?

Research has shown that peer support can benefit people with alcohol-related liver disease (ALD). Studies have found that programs like peer support help individuals reduce alcohol consumption, which is crucial for preventing further liver damage. Peer support also addresses gaps in care by providing emotional and social support, leading to better engagement in medical treatment. Some evidence suggests that participants in peer support programs may experience fewer alcohol relapses and improved survival rates. Overall, peer support is considered a promising method to aid liver transplant recipients in recovery, particularly those with a history of alcohol issues.12678

Who Is on the Research Team?

PC

Po-Hung Chen, MD, PhD

Principal Investigator

Johns Hopkins University

Are You a Good Fit for This Trial?

This trial is for individuals who have had a liver transplant due to alcohol-related liver disease. It aims to help them with recovery by providing peer support. Participants should not be currently involved in any other similar intervention studies.

Inclusion Criteria

English speakers
Has 1 to 3 years of continuous alcohol abstinence at the time of trial entry
I had a liver transplant due to liver disease from alcohol.

Exclusion Criteria

I received a liver transplant and did not have alcohol-related liver disease.
I am unable to understand or sign the consent form.
Active participation in a separate intervention trial for alcohol use disorder

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Peer Support Intervention

Participants receive support from Peer Support Specialists (PSS) who have lived experiences with ALD/LT. PSS provide brief counseling, active listening, and meet with participants at regular intervals.

1 year

Follow-up

Participants are monitored for alcohol consumption, engagement in medical care, and overall survival.

1 year

What Are the Treatments Tested in This Trial?

Interventions

  • Peer Support

Trial Overview

The study is testing whether having a Peer Support Specialist (PSS) can reduce the chances of patients returning to alcohol use and improve their engagement with medical care post-liver transplant.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Peer Support Specialist (PSS)Experimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Johns Hopkins University

Lead Sponsor

Trials
2,366
Recruited
15,160,000+

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Collaborator

Trials
865
Recruited
1,091,000+

Citations

Enhancing care in alcohol-associated liver disease ... - PMC

Alcohol use disorder (AUD) and alcohol-associated liver disease (ALD) are interconnected conditions that contribute significantly to global morbidity and ...

Peer Support for Liver Transplant Recipients With History ...

This clinical trial will examine the impact of peer support specialists (PSS) on the recovery experience of individuals who received LT for ALD.

Enhancing care in alcohol-associated liver disease through...

Despite advances in medical management, care for individuals with AUD and ALD remains suboptimal due to persistent gaps in psychosocial support, stigma, and ...

Efficacy of psychosocial interventions to reduce alcohol use in ...

Alcohol abstinence is the therapeutic hallmark to prevent further liver injury (National Institute for Health and Care Excellence 2011; British ...

Systematic review: Interventions for alcohol use disorder in ...

We also recorded whether studies reported on clinical outcomes (mortality, hospitalisation, hepatic decompensation), alcohol intake outcomes ( ...

Peer Support for Alcoholic Liver Disease (THRIVES Trial)

The THRIVES medical study, being run by Johns Hopkins University, needs participants to evaluate whether Peer Support will have tolerable ...

Enhancing care in alcohol-associated liver disease ...

Affiliations. 1 Sober Livers, Fatty Liver Foundation, Denver, Colorado, USA. 2 Transplant Recipient International, Temple, Texas, USA.

Treatment of alcohol use disorder in patients with liver ...

Acamprosate is a good choice, as it prevents relapse to drinking with a number needed to treat of 12. There are no reports indicating high risks of liver ...