Spermidine for Aging

This trial tests spermidine, a dietary supplement, to assess its effects on aging. Researchers aim to evaluate its safety, tolerability, and any bodily changes it may cause. Participants will take increasing doses of spermidine over three months. The trial seeks adults without recent major organ issues and not on medications affecting the immune system. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research on aging and health.

The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are on immunomodulatory medications or any therapy that might affect the study agent. It's best to discuss your specific medications with the trial investigator.

Research has shown that spermidine supplements are safe and generally well-tolerated. Studies have found that a spermidine-rich extract is safe for both mice and older adults. In one study, healthy men took 40 mg of spermidine daily for 28 days without any safety issues. Additionally, administering spermidine to mice throughout their lives did not cause harmful effects. These findings suggest that spermidine is usually well-tolerated in various amounts and situations.¹²³⁴⁵

Spermidine is unique because it targets aging at the cellular level by promoting autophagy, a process that helps clean out damaged cells, which is not a focus of most traditional treatments for aging. Common treatments often include lifestyle adjustments, supplements, and medications targeting symptoms, but spermidine works differently by enhancing this self-renewal process. Researchers are excited about spermidine because it could address aging's root causes rather than just its symptoms, potentially improving overall health and longevity. Additionally, the escalating dosage approach in its administration could optimize its effectiveness and safety for users.

Research suggests that spermidine might help slow down aging. In studies with mice, it increased their lifespan by about 10% and improved heart health as they aged. Some research also indicates that spermidine could lessen the impact of age-related diseases. It may work by helping cells clean up and recycle waste, a process called autophagy, which is important for maintaining cell health. However, at lower doses like 40 mg per day, its effects on humans have been minimal. Overall, spermidine seems promising, but more research is needed to confirm its benefits for people. Participants in this trial will receive escalating doses of spermidine to further investigate its potential effects on aging.³⁶⁷⁸⁹