360 Participants NeededMy employer runs this trial

Memory Decisions for Aging

CB
Overseen ByCaitlin Bowman, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Caitlin Bowman
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to understand how the brain supports memory decisions in both young and older adults. Researchers seek to determine if older adults combine past experiences differently when making memory decisions compared to younger individuals. Participants will engage in a memory task while researchers measure their brain activity. The trial seeks right-handed, fluent English speakers who are cognitively healthy and have normal or corrected vision. It excludes individuals with neurological disorders or conditions that make MRI scans unsafe. As an unphased trial, this study offers a unique opportunity to contribute to the scientific understanding of memory across different age groups.

Do I have to stop taking my current medications for the trial?

The trial protocol does not specify whether you need to stop taking your current medications. However, if you have uncontrolled hypertension, diabetes, or thyroid disorder, you may not be eligible to participate.

What prior data suggests that this protocol is safe for participants?

Research shows that as people age, they often rely more on past experiences when making decisions. This is a normal part of aging and doesn't directly affect health. Studies suggest that older adults might take fewer risks and make decisions more quickly than younger people. The brain adjusts to these changes, and no evidence indicates that this process is harmful or unsafe. Overall, reports do not indicate negative effects or safety concerns related to how aging influences decision-making.12345

Why are researchers excited about this trial?

Researchers are excited about the Memory Decision type treatment because it introduces a novel approach to enhancing decision-making processes in aging individuals. Unlike traditional therapies that focus on symptom management or cognitive training, this method aims to directly engage and improve memory-based decision-making. This innovative focus could potentially offer a more precise way to address cognitive challenges associated with aging, leading to enhanced daily functioning and quality of life for older adults.

What evidence suggests that this trial's treatments could be effective for memory decisions in aging?

Research shows that older adults often use various methods of remembering, such as recalling details or recognizing familiar items, when making decisions. Some studies suggest that older adults might take longer to decide than younger people. However, they can adapt their decision-making to better suit real-life situations. Despite challenges with memory and thinking speed, older adults excel at managing emotions, aiding their decision-making. While younger adults might perform better on certain tasks, older adults contribute valuable experience and emotional control to their decisions.56789

Are You a Good Fit for This Trial?

This study is for healthy, right-handed adults aged 18-30 or 65-80 who speak English and have normal thinking abilities. Participants must have normal or corrected vision and be able to lie still in an MRI scanner. People with certain medical conditions, neurological disorders, or MRI safety risks cannot join.

Inclusion Criteria

Fluent in English
I am between 18-30 or 65-80 years old.
Right-handed
See 2 more

Exclusion Criteria

I have uncontrolled high blood pressure, diabetes, or thyroid problems.
Having conditions or devices that are unsafe for MRI (assessed via imaging center's MRI safety screening form)
Self-reported neurological disorder (e.g., Alzheimer's or Parkinson's disease)
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Experimental Session

Participants complete a memory task while undergoing functional MRI to measure brain responses

1 session
1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after the experimental session

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Memory decision type

Trial Overview

The trial studies how young and older adults make memory decisions by having them complete a memory task while their brain activity is measured using functional MRI. Researchers will compare how the two age groups use past experiences during these tasks.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Experimental ArmExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Caitlin Bowman

Lead Sponsor

National Institute on Aging (NIA)

Collaborator

Trials
1,841
Recruited
28,150,000+

Citations

The Impact of Episodic Memory on Decision-Making in Aging

This work aimed to examine the role of two memory processes, recollection and familiarity, in decision-making in ageing.

Full article: Age-Related Differences in Decision-Making

Older adults tend to exhibit longer response times than younger adults in choice tasks across cognitive domains, such as perception, attention, ...

New Research Findings May Help Older People Make ...

One experiment found that older adults made more conservative decisions about several hypothetical medical situations than younger people did.

A Review of Decision-Making Processes: Weighing the Risks ...

The first is older adults' increased effectiveness of emotion regulation. Both self-reports and actual emotional experience indicate that older adults are ...

Cognitive Aging and the Adaptive Selection of Decision ...

Are older adults' decision abilities fundamentally compromised by age-related cognitive decline? Or can they adaptively select decision strategies?

Aging and Decision-making: A Conceptual Framework ... - PMC

The present review proposes an overarching conceptual framework with the aim of connecting disjointed aspects of this field of research.

Ageing and Decision-making: A systematic review ...

The small number of studies that have explored age-differences in social, health and safety decision-making have produced inconsistent results.

The Impact of Episodic Memory on Decision-Making in Aging

By recalling past experiences, individuals can assess the long-term consequences of their choices and avoid repeating negative outcomes. This ...

How Decision-Making Changes With Age

A large body of research shows that as we age, we draw more on prior experiences, take fewer risks, and make decisions more quickly.