HMB + 2-HOBA for Aging

(H2AGE Trial)

This trial aims to determine how different supplements might address aging-related issues, such as muscle strength and overall health. Participants will receive either β-hydroxy-β-methylbutyrate (HMB), 2-hydroxybenzylamine (2-HOBA), both, or a placebo, while researchers monitor their health and any side effects. Ideal candidates for this trial are individuals aged 65 or older who speak English or French and are willing to maintain their current lifestyle and diet throughout the study. As an unphased trial, this study allows participants to contribute to valuable research on aging and potentially enhance their own health.

You may need to stop certain medications or supplements that affect muscle metabolism or immune function, like glucocorticoids or excessive protein supplements. If you're on a stable dose of allowed medications for at least 3 months, you can continue them, but any changes must be reported.

Previous studies have shown that both HMB and 2-HOBA are safe and well-tolerated in humans. HMB, a nutritional supplement, has been used safely in studies with individuals over 50, showing no significant side effects, including no changes in liver or kidney function, which are important safety measures. Long-term use of HMB, even for up to a year, has been considered safe.

2-HOBA has also undergone safety testing in humans. It was safe and well-tolerated at doses up to 825 mg, with no major side effects reported, even with repeated use. Research has shown that it does not cause cell damage or mutations.

Researchers are excited about these treatments for aging because they introduce unique combinations of ingredients that aren't typically used together in this context. HMB (β-hydroxy-β-methylbutyrate) is known for supporting muscle health, while 2-HOBA (2-hydroxybenzylamine) is being explored for its antioxidant properties. When combined, these compounds may offer a dual approach by supporting muscle maintenance and reducing oxidative stress, which is different from standard aging treatments like lifestyle changes or nutritional supplements. Additionally, the inclusion of cholecalciferol (Vitamin D3) could enhance the benefits by supporting bone health. This combination approach has the potential to offer more comprehensive benefits than traditional methods.

Research has shown that HMB, which participants in this trial may receive, can help older adults increase muscle mass, strength, and physical function. Studies indicate that HMB reduces muscle loss and improves muscle health, which is particularly beneficial as people age. Meanwhile, 2-HOBA, another treatment option in this trial, has demonstrated potential in lowering inflammation and supporting the immune system. It protects the body from harmful molecules that can damage cells. While results can vary among individuals, evidence suggests that both supplements, tested in separate arms of this trial, may improve health outcomes related to aging.¹³⁶⁷⁸