Exercise for Adverse Childhood Experiences
(CTEC Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how different types of exercise can improve thinking and memory in middle-aged adults who experienced childhood abuse or neglect. It compares the effects of short-term and long-term moderate exercise to determine which benefits cognitive health more. Participants will engage in either a nine-week moderate exercise program, short bouts of moderate exercise, or light exercise serving as a placebo. Individuals with memory or attention complaints who experienced childhood adversity might be a good fit for this trial. As an unphased trial, it offers participants the chance to contribute to groundbreaking research that could enhance cognitive health strategies for those with similar backgrounds.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that moderate exercise is generally safe and well-tolerated, even for individuals with difficult childhoods. One study found that increased activity improved the quality of life for adults with such backgrounds. Another study demonstrated that gradually increasing exercise enhanced heart and mental health in young women who faced childhood trauma.
For a single day of moderate exercise, findings suggest that physical activity can help reduce negative effects related to difficult childhoods, such as depression. Overall, these studies provide reassuring evidence that both short-term and long-term moderate exercise can be safe for participants, with few reports of negative effects.12345Why are researchers excited about this trial?
Researchers are excited about using exercise to address the effects of Adverse Childhood Experiences (ACEs) because it offers a natural, accessible approach compared to conventional therapies like medication or counseling. Unlike standard treatments that often focus on managing symptoms through pharmaceuticals or psychotherapy, moderate intensity exercise may help improve both mental and physical health by enhancing mood and cognitive function. This trial is exploring different exercise regimens, including a 9-week program, to see if they can provide quicker and more sustainable benefits for individuals with a history of ACEs. This method is appealing because it leverages the body's natural processes to potentially deliver holistic benefits, offering a promising alternative to traditional treatment paths.
What evidence suggests that this trial's exercise interventions could be effective for cognitive complaints in middle-aged adults with a history of childhood abuse or neglect?
Research has shown that exercise can enhance both mental and physical health in individuals with adverse childhood experiences (ACEs). This trial will explore various exercise regimens. Participants in the "Chronic Exercise Moderate" arm will engage in regular, moderate exercise over several weeks. Studies indicate this can improve heart health and may reduce feelings of depression and anxiety. Meanwhile, the "Acute Exercise Moderate first" and "Acute Exercise Light first" arms will assess the effects of short periods of exercise, such as a single day of moderate activity, which have been linked to a better quality of life. Physical activity can mitigate some negative effects of ACEs, offering a promising way to enhance well-being for those affected.46789
Who Is on the Research Team?
Erin Logue, PhD
Principal Investigator
University of Texas at Austin
Are You a Good Fit for This Trial?
This trial is for middle-aged adults (40-60 years old) who experienced childhood abuse or neglect, have cognitive complaints but are medically healthy. They must speak English fluently and not have severe mental health issues, substance abuse problems, major medical conditions, or engage in high-intensity activities.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Initial Assessment
Initial assessment including symptom measures and neuropsychological testing
Acute Exercise Condition 1
First acute exercise condition in lab, followed by symptom measures and neuropsychological testing
Acute Exercise Condition 2
Second acute exercise condition in lab, followed by symptom measures and neuropsychological testing
Chronic Exercise Intervention
9-week exercise intervention or activity as usual outside of lab, with assessments at 3-week intervals
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Moderate Intensity Exercise (9 wks)
- Moderate Intensity Exercise (one day)
- Placebo - Light Intensity Exercise (one day)
Trial Overview
The study tests how different exercise intensities affect cognition over a period of up to 78 days. Participants will undergo initial assessments followed by acute exercises in the lab and a longer-term exercise regimen or their usual activity with regular cognitive testing.
How Is the Trial Designed?
4
Treatment groups
Experimental Treatment
Active Control
9-weeks Moderate Intensity Exercise Day 36 (at 3 weeks) Assessments Day 57 (at 6 weeks) Assessments Day 78 (at 9 weeks) Assessments
Day 1 Assessments, Day 8 Moderate Intensity Exercise (followed by symptom measures and neuropsychological tests), Day 15 Light Intensity Exercise (symptom measures and neuropsychological tests)
9-week activity as usual Day 36 (at 3 weeks) Assessments Day 57 (at 6 weeks) Assessments Day 78 (at 9 weeks) Assessments
Control Day 1 Assessments (symptom measures, neuropsychological tests, and cognitive complaints interview), Day 8 Light Intensity Exercise (followed by symptom measures and neuropsychological tests), Day 15 Moderate Intensity Exercise (symptom measures and neuropsychological tests)
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Texas at Austin
Lead Sponsor
Citations
Progressive exercise training improves cardiovascular ...
Progressive exercise training improves cardiovascular psychophysiological outcomes in young adult women with a history of adverse childhood ...
Associations Between Adverse Childhood Experiences ...
To determine the associations between Adverse Childhood Experiences (ACEs), adolescent screen time, and physical activity during the early COVID-19 pandemic.
Moderating Effects of Physical Activity on the Relationship ...
Our findings suggest that improvement of PA level is a significant predictor of improved HRQOL of adults with ACEs. Keywords: adverse childhood experiences, ...
4.
journals.humankinetics.com
journals.humankinetics.com/view/journals/jpah/19/12/article-p847.xml?rskey=yYHynM&result=78&printJournal of Physical Activity and Health
Background: Adverse childhood experiences (ACEs) may be associated with worse physical and mental health in adulthood, and low physical ...
5.
escholarship.org
escholarship.org/content/qt3b95k3vk/qt3b95k3vk_noSplash_f421456f53fb495871fa035d0c9e482d.pdfAssociations Between Adverse Childhood Experiences, ...
a higher ACE score was associated with significantly greater hours per day of screen time and fewer hours per week of physical activity. ...
The Impact of Adverse Childhood Experiences on Health and ...
Researchers found a 30-fold increase in learning or behavior problems (as reported by parents) between children with high ACE scores (4 or more) compared to ...
Adverse Childhood Experiences (ACEs) | VitalSigns
ACEs are potentially traumatic events that occur in childhood. ACEs can include violence, abuse, and growing up in a family with mental health or substance use ...
8.
txicfw.socialwork.utexas.edu
txicfw.socialwork.utexas.edu/adverse-childhood-experiences-aces-study/Adverse Childhood Experiences (ACE) Study
A higher ACE score correlates with later negative health outcomes, including early death, for some. The fact that trauma impacts motivation and behavior
9.
researchgate.net
researchgate.net/publication/348574383_Adverse_childhood_experiences_ACEs_youth_sports_participation_Does_a_gradient_existAdverse childhood experiences (ACEs) & youth sports ...
Results Of 23,557 youth included in our study (12,454 boys [51%], 11,303 girls [49%]; 21.9% reported 1 ACE, 10.1% reported 2 ACEs, and 14.3% reported 3 or more ...
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