Intraosseous Vancomycin for Total Knee Replacement
(IO Vanco Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This is a prospective, single-center, open-label study evaluating systemic vancomycin levels following preoperative intraosseous administration in patients undergoing primary unilateral total knee arthroplasty. Eligible participants will receive preoperative intraosseous vancomycin (500 mg in 100 mL saline) as part of standard perioperative infection prophylaxis. The study is open-label due to the nature of the intervention. Blood samples will be collected at predefined time points intraoperatively to measure serum vancomycin concentrations. Patients will be randomized to either a tourniquet or no tourniquet for these blood draws.
Are You a Good Fit for This Trial?
This trial is for adults over 18 having their first knee replacement surgery at UC San Diego who can give consent and are suitable to receive vancomycin through the bone.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Preoperative Treatment
Participants receive preoperative intraosseous vancomycin as part of standard perioperative infection prophylaxis
Intraoperative Monitoring
Blood samples are collected at predefined time points intraoperatively to measure serum vancomycin concentrations
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Vancomycin
Trial Overview
The study tests giving vancomycin (an antibiotic) directly into the bone before knee replacement surgery, then measures how much of it gets into the blood. Patients are randomly assigned to have a tourniquet or not during these measurements.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
TKA IO Vancomycin Administration with tourniquet
TKA IO Vancomycin administration with no tourniquet.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, San Diego
Lead Sponsor
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