Empagliflozin for High Blood Pressure
(NEURO-EMPA Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this clinical trial is to examine whether empagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, improves vascular and autonomic function in adults with prehypertension. The main questions this clinical trial aims to answer are:
1. Does empagliflozin improve endothelial function?
2. Does empagliflozin improve sympathetic nervous system function?
This clinical trial employs a double-blind, placebo-controlled crossover study lasting up to 6 weeks for participants with prehypertension and up to 2 weeks for normotensive participants. Participants with prehypertension will take empagliflozin or placebo for 2 weeks, separated by a 2-week washout. Normotensive participants will complete baseline, pre-treatment visits only and will serve as a control group.
Who Is on the Research Team?
Kanokwan Bunsawat, PHD
Principal Investigator
University of Iowa
Are You a Good Fit for This Trial?
This trial is for adults with prehypertension (slightly high blood pressure) or normal blood pressure. Participants should not have other major health issues that could interfere with the study.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Empagliflozin
Trial Overview
The study tests whether empagliflozin, a diabetes medication, can improve blood vessel and nervous system function compared to a placebo. It uses a double-blind crossover design where participants receive both treatments at different times.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
Participants will receive Empagliflozin (25 mg once a day) for 2 weeks.
Participants will receive placebo pills identical in appearance and taste.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Kanokwan Bunsawat
Lead Sponsor
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