Personalized Analgesia Through Central Nervous System Engagement to Unlock Performance
(PACE-UP Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this clinical trial is to examine the effects of duloxetine on walking ability and physical activity in patients with knee osteoarthritis. Researchers will compare duloxetine to a placebo (a look-alike substance that contains no drug) to see if duloxetine works to improve walking ability in patients with knee osteoarthritis. At study visits, participants will complete surveys, perform physical function tasks, undergo non-invasive brain imaging, and undergo sensory testing.
Who Is on the Research Team?
Benedict Alter, MD, PhD
Principal Investigator
University of Pittsburgh
Are You a Good Fit for This Trial?
What Are the Treatments Tested in This Trial?
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
In Period A, participants will receive placebo. In Period B, participants will receive duloxetine.
In Period A, participants will receive duloxetine. In Period B, participants will receive placebo.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Benedict Alter
Lead Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborator
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