Vasoactive Medication for Kidney Transplant
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this clinical trial is to learn if vasopressin improves the body's response to intravenous fluids during kidney transplantation in patients who have relaxed blood vessels. Researchers will compare the results of vasopressin to those who received calcium chloride.
Are You a Good Fit for This Trial?
This trial is for adults 18 or older who are having a kidney transplant at Cedars-Sinai Medical Center and can give informed consent.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Intraoperative
Participants undergo intraoperative circulation phenotyping and receive phenotype-guided vasoactive medication during kidney transplantation
Postoperative Follow-up
Participants are monitored for delayed graft function and other postoperative outcomes
What Are the Treatments Tested in This Trial?
Interventions
- Phenotype-Guided Vasoactive Management
Trial Overview
The study compares two ways to manage blood pressure during kidney transplants: using vasopressin based on the patient's condition versus giving calcium chloride. The goal is to see which method helps fluids work better in patients with relaxed blood vessels.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Recipients undergo intraoperative circulation phenotyping using pulse contour monitoring and fluid responsiveness testing. Vasoactive support is assigned according to phenotype: vasopressin infusion for Hyperdynamic physiology, norepinephrine infusion for Mixed Physiology, calcium chloride and/or low-dose dopamine for Poor Contractility, and fluid-guided support for Normal physiology.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Jennifer Cutler
Lead Sponsor
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