Glucagon for Low Blood Sugar After Bariatric Surgery
What You Need to Know Before You Apply
What is the purpose of this trial?
In this study, the investigators will determine (a) whether metabolism (secretion and turnover) of glucagon is altered in patients with PBH, (b) whether this is affected by a meal, (c) whether PBH affects the ability of the body to produce glucose (endogenous glucose production), and (d) whether PBH affects the amount of glycogen in the liver (storage form of glucose) when fasting and after a meal. The investigators will determine the effect of glucagon to raise glucose levels after a meal. To answer these questions, participants will receive an infusion of a stable (nonradioactive) isotope of glucose and glucagon, and a meal containing a stable isotope of glucose. Glycogen will be measured by magnetic resonance imaging (MRI) of the liver before and after the meal. This information will be used to develop computer models for the glucagon pump system.
Who Is on the Research Team?
Ananda Basu, MD
Principal Investigator
University of Alabama at Birmingham
Mary-Elizabeth Patti, MD
Principal Investigator
Joslin Diabetes Center
Are You a Good Fit for This Trial?
This trial is for adults who have had gastric bypass surgery, with or without experiencing low blood sugar after meals (post-bariatric hypoglycemia). Participants should not have other major health issues that could interfere with the study.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Glucagon for Injection
Trial Overview
Researchers are studying how the body processes glucose and glucagon after a meal in people with and without post-bariatric hypoglycemia. This involves infusions of safe, nonradioactive forms of glucose and glucagon, eating a test meal, and liver scans before and after eating.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Individuals that underwent RYGB at least 2 years prior to recruitment and have a diagnosis of PBH.
Individuals that underwent Roux-en-y gastric bypass (RYGB) at least 2 years prior to recruitment and do not have a diagnosis of PBH.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Joslin Diabetes Center
Lead Sponsor
University of Alabama at Birmingham
Collaborator
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator
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