Tirzepatide for Heart Failure and Obesity
What You Need to Know Before You Apply
What is the purpose of this trial?
The central hypothesis to be tested is that patients with obesity and heart failure with preserved ejection fraction (HFpEF) prescribed tirzepatide will demonstrate reductions in measured plasma volume. In conjunction with state-of-the-art body composition analysis and measures of adipokines, this will establish an important mechanism of clinical benefit and inform disease pathophysiology. To accomplish this, this study will perform a 15-month prospective cohort study in 50 patients with obesity and HFpEF who clinically qualify for treatment with tirzepatide. The investigators will serially measure plasma volume and body composition with quantitative magnetic resonance to determine changes over time with tirzepatide treatment.
Who Is on the Research Team?
Elissa A Driggin, MD
Principal Investigator
Columbia University
Are You a Good Fit for This Trial?
This trial is for adults with obesity (BMI over 30) and a specific type of heart failure called HFpEF, who have moderate symptoms and stable heart medications. Participants must meet certain heart function criteria based on recent tests.Inclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Tirzepatide
Trial Overview
The study is testing tirzepatide, a medication given to people with both obesity and HFpEF, to see if it can reduce blood plasma volume and improve body composition over 15 months. About 50 participants will be closely monitored during the study.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
After a 3-month control period, participants will be prescribed tirzepatide and undergo serial plasma volume measurement and body composition analysis. Participants will be prescribed tirzepatide under the brand name Monjauro if they have diabetes, and under the brand name Zepbound if they do not have diabetes. All participants will be initiated on an initial dose of 2.5 mg injected subcutaneously in the thigh or abdomen every week on same day and at the same time.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Columbia University
Lead Sponsor
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