Veligrotug for Thyroid Eye Disease

Not yet recruiting at 7 trial locations
JS
Overseen ByJames Sankan
Age: 18+
Sex: Any
Trial Phase: Phase 4
Sponsor: Viridian Therapeutics, Inc.
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

This is a clinical trial to evaluate the safety and efficacy of veligrotug (LUMVOA™) in participants with moderate to severe TED who previously received and responded to an initial course of teprotumumab treatment but subsequently had a disease recurrence.

Are You a Good Fit for This Trial?

This trial is for people with moderate to severe thyroid eye disease (TED) who previously improved after teprotumumab treatment but then had their symptoms return. Participants must have a confirmed diagnosis and meet certain health requirements.

Inclusion Criteria

Must agree to use highly effective contraception as specified in the protocol
My eye condition came back after finishing teprotumumab treatment.
I finished 8 teprotumumab infusions at least 9 months ago.
See 5 more

Exclusion Criteria

Must not have abnormal hearing test before first dose or any history of hearing impairment
I do not have sight-threatening thyroid eye disease.
I do not have an eye condition that would affect the study results.
See 8 more

What Are the Treatments Tested in This Trial?

Interventions

  • veligrotug (LUMVOA™)

Trial Overview

The study is testing the safety and effectiveness of veligrotug (LUMVOA™), a new medication, in treating TED that has come back after initial improvement with teprotumumab. All participants will receive veligrotug.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: 5 IV infusions of 10 mg/kg of veligrotugExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Viridian Therapeutics, Inc.

Lead Sponsor

Trials
7
Recruited
1,200+