Stannous Fluoride Toothpaste for Gum Disease

This trial tests the effectiveness of two kinds of toothpaste with stannous fluoride against gum disease compared to regular toothpaste. The goal is to determine if these special toothpastes can reduce gingivitis symptoms (gum inflammation) after 12 weeks of use. Individuals with mild to moderate gum disease and noticeable bleeding when brushing might be suitable for this study. Participants must use only the study's toothpaste and avoid other dental products during the trial. As a Phase 4 trial, this research involves an FDA-approved treatment, aiming to understand its benefits for more patients.

The trial does not specify if you need to stop taking your current medications, but you cannot have taken certain medications like antibiotics, anti-inflammatories, or anti-coagulants within 4 weeks before starting the study.

Studies have shown that stannous fluoride toothpaste is safe for use. This toothpaste helps prevent gum disease and cavities. Research indicates it can reduce gum swelling and combat bacteria that cause plaque. Stannous fluoride works by killing bacteria and inhibiting their growth.

Researchers are excited about the stannous fluoride toothpaste for gum disease because it uses 0.454% stannous fluoride, which is known for its antimicrobial properties. Unlike standard toothpastes that often use sodium monofluorophosphate as the active ingredient, stannous fluoride not only helps prevent cavities but also targets bacteria that cause gum disease. This dual action could offer a more comprehensive approach to oral health, potentially reducing gum inflammation and improving overall gum health more effectively than current options.

This trial will compare different toothpaste formulations for their effectiveness in reducing gum disease. Research has shown that stannous fluoride toothpaste, which participants in this trial may receive, helps reduce gum disease. Specifically, studies have found that using toothpaste with 0.454% stannous fluoride can decrease plaque and gum inflammation after just two weeks. Over six months, participants have demonstrated noticeable improvements in gum health and a reduction in harmful substances in the mouth. This toothpaste can also help reverse gum inflammation and reduce bleeding gums. Overall, stannous fluoride toothpaste is a strong tool for fighting gingivitis and improving oral health.⁴⁶⁷⁸⁹