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40 Participants NeededMy employer runs this trial

Discontinuation of Antiseizure Medication for Epilepsy

(STOP-ASM Trial)

ST
Overseen BySamuel Terman, MD, MS
Age: 18+
Sex: Any
Trial Phase: Phase 4
Sponsor: University of Michigan
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

The main purpose of this study is to understand the effects of continuing versus discontinuing antiseizure medications after a period of seizure-freedom. Physician guidelines endorse that after a period of seizure-freedom, the risk of another seizure may be low enough to allow patients to consider coming off antiseizure medication to see if they still need it. However, evidence is limited regarding how much continuing antiseizure medication still reduces seizures versus increases side effects after a patient has been treated for a while. This study will determine whether discontinuing antiseizure medications benefits patients.

Who Is on the Research Team?

ST

Samuel Terman, MD, MS

Principal Investigator

University of Michigan

Are You a Good Fit for This Trial?

This trial is for people with epilepsy who have been free of seizures for a period of time and are considering whether to stop taking their antiseizure medication. Participants should be stable and under medical supervision.

Inclusion Criteria

At most 35% calculated 1-year post-discontinuation seizure risk based upon the existing multivariable calculator if on only 1 ASM, no restriction if on more than 1 ASM
Provision of signed and dated informed consent form
Stated willingness to comply with all study procedures and availability for the duration of the study
See 4 more

Exclusion Criteria

I have a large abnormal area in my brain seen on imaging scans.
Current pregnancy or planned pregnancy during the study period
I have had surgery to treat my epilepsy.
See 1 more

What Are the Treatments Tested in This Trial?

Trial Overview

The study compares what happens when patients either continue or discontinue their antiseizure medications after being seizure-free, to see which option leads to better outcomes.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Discontinue antiseizure medicationsExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Michigan

Lead Sponsor

Trials
1,891
Recruited
6,458,000+

National Institute on Aging (NIA)

Collaborator

Trials
1,841
Recruited
28,150,000+

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