Montelukast for Type 2 Diabetes
(MIRACLE-T2D Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
Diabetes mellitus type 2 is associated with significant morbidity and mortality; and identifying new treatments for diabetes complications to be used alone or in combination with other therapies is a high priority. Hyperglycemia triggers proinflammatory pathways leading to damage in the kidneys, eyes and blood vessels; thus targeting proinflammatory lipid mediators called leukotrienes may represent a promising therapy for diabetes complications. This clinical trial seeks to investigate whether montelukast, a leukotriene antagonist, improves kidney, eye and vascular function in adult participants with type 2 diabetes and kidney disease.
Who Is on the Research Team?
Jessica Kendrick, MD MPH
Principal Investigator
University of Colorado, Denver
Are You a Good Fit for This Trial?
This trial is for adults with type 2 diabetes who also have kidney disease. Participants should not have other major health issues that would prevent safe participation.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Montelukast
Trial Overview
The study tests whether montelukast, a medication usually used for asthma and allergies, can help protect the kidneys, eyes, and blood vessels in people with type 2 diabetes compared to a placebo (inactive pill).
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
10 mg capsule by mouth daily
One matching capsule by mouth daily
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Colorado, Denver
Lead Sponsor
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