Fluorescent Probe for Increased Kidney Clearance

(FLARE Trial)

This trial tests a new device called the transdermal glomerular filtration (tGFR) monitor, which allows doctors to measure kidney function more accurately and in real-time. Current methods, such as urine collection or blood tests, can be inconvenient or unreliable, especially for sick patients. The trial compares this new device with traditional methods in hospitalized patients. It seeks critically or acutely ill patients in the intensive care unit with normal kidney function to participate. As a Phase 4 trial, the tGFR monitor has already received FDA approval and proven effective, and this research aims to understand how it benefits more patients.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research has shown that the MediBeacon Transdermal GFR System (tGFR) is safe and well-tolerated by patients. Previous studies found no serious side effects from using the device. The FDA has approved the system, indicating its safety for assessing kidney function in individuals with both healthy and impaired kidneys.

Researchers are excited about the MediBeacon Transdermal Glomerular Filtration Rate (GFR) Monitoring because it offers a new, non-invasive way to measure kidney function. Unlike traditional methods, such as blood tests using substances like Iohexol, this technique utilizes a fluorescent probe that can be monitored through the skin, eliminating the need for blood draws. This method could provide real-time kidney health assessments, making it easier and more comfortable for patients to track their kidney function.

Research has shown that the MediBeacon transdermal GFR (tGFR) system, which participants in this trial may receive, effectively measures kidney function. Studies indicate it accurately tracks the glomerular filtration rate (GFR), a key measure of kidney function. In one study, the tGFR system demonstrated 94% accuracy compared to traditional blood tests. This system offers a non-invasive method to monitor kidney function in real-time, which is particularly useful for patients with fluctuating kidney health. Additionally, the FDA has approved it for use in individuals with both normal and impaired kidney function.¹²⁴⁶⁷