76 Participants NeededMy employer runs this trial

Erector Spinae Plane Block vs Trigger Point Injection for Back Pain

Recruiting at 4 trial locations
RD
Overseen ByRyan D'Souza, MD
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores two types of injections to help people with chronic mid-back pain. Researchers aim to determine which treatment—the erector spinae plane (ESP) block or trigger point injection (TPI)—provides better relief, improves physical function, boosts emotional well-being, and achieves higher patient satisfaction. Participants will be randomly assigned to receive one of these treatments and monitored for 12 weeks through questionnaires and pain assessments. Ideal candidates for this trial are adults who have experienced chronic mid-back pain for at least three months and have intense pain with specific patterns in their back muscles. As a Phase 4 trial, this study involves treatments already FDA-approved and proven effective, aiming to understand how they can benefit more patients.

What is the safety track record for these treatments?

Research has shown that both the Erector Spinae Plane (ESP) block and Trigger Point Injection (TPI) are generally safe for managing pain.

The ESP block, a type of regional anesthesia, numbs a specific area of the body. Studies have found it to be well-tolerated, with few complications. However, most safety information comes from individual case reports, so detailed data remains limited.

Trigger Point Injections also have a strong safety record. Research indicates that using anesthetics like bupivacaine without steroids results in minimal complications. Common side effects are usually mild, such as temporary discomfort or numbness at the injection site.

Both treatments have been safely used in various settings, supporting their effectiveness in managing pain.12345

Why are researchers enthusiastic about this study treatment?

Researchers are excited about these treatments for back pain because they offer innovative approaches to pain management. The Erector Spinae Plane (ESP) Block uses ultrasound guidance to deliver anesthetic directly into the fascial plane around the erector spinae muscle, potentially providing more targeted pain relief with fewer side effects compared to systemic medications like opioids or NSAIDs. On the other hand, Trigger Point Injections (TPI) focus on relieving muscle knots by injecting anesthetic directly into the areas of muscle tension, offering a localized treatment option for muscle-related pain. Both methods aim to provide rapid pain relief through precise administration of bupivacaine, reducing reliance on oral pain medications and minimizing systemic exposure.

What evidence suggests that this trial's treatments could be effective for chronic thoracic pain?

This trial will compare the effectiveness of the erector spinae plane (ESP) block and trigger point injections (TPI) for back pain. Research has shown that the ESP block can effectively reduce chronic pain. For instance, patients with long-term lower back pain reported about 90% improvement after receiving the ESP block. In another study, the ESP block significantly reduced pain compared to a placebo. Meanwhile, TPI relieves pain by injecting medicine directly into tight muscle areas. Although few studies directly compare these two treatments for chronic upper back pain, both have shown promise in reducing pain in various situations.46789

Who Is on the Research Team?

RD

Ryan D'Souza, MD

Principal Investigator

Mayo Clinic

Are You a Good Fit for This Trial?

This trial is for adults with ongoing mid-back muscle pain (chronic thoracic myofascial pain). Participants should have back pain that hasn't responded well to other treatments. People with certain medical conditions or allergies may not be able to join.

Inclusion Criteria

I have had ongoing chest muscle pain for at least three months.
My pain level is 4 or higher on a scale from 0 to 10.
I have at least two of these: back pain, tight muscle band, or pain spreading when pressed.
See 1 more

Exclusion Criteria

I have had surgery on my neck or upper back.
History of substance use disorder
I have thoracic radiculopathy.
See 11 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either an ultrasound-guided thoracic erector spinae plane (ESP) block or trigger point injection (TPI) for chronic thoracic myofascial pain

Day 0 (procedure day)
1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment through questionnaires and pain assessments

12 weeks
Multiple visits (in-person and virtual)

What Are the Treatments Tested in This Trial?

Interventions

  • Erector Spinae Plane (ESP) Block with 0.5% Plain Bupivacaine
  • Trigger Point Injection (TPI) with 0.5% Plain Bupivacaine

Trial Overview

The study compares two injection treatments for chronic mid-back pain: the erector spinae plane (ESP) block and trigger point injections (TPI), both using bupivacaine. Participants are randomly assigned to one treatment and followed for up to 12 weeks.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: Erector Spinae Plane (ESP) BlockExperimental Treatment1 Intervention
Group II: Trigger Point Injection (TPI)Active Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials
3,427
Recruited
3,221,000+

M.D. Anderson Cancer Center

Collaborator

Trials
3,107
Recruited
1,813,000+

Ohio State University

Collaborator

Trials
891
Recruited
2,659,000+

University of Maryland, Baltimore

Collaborator

Trials
729
Recruited
540,000+

Citations

A randomized clinical trial of erector spinae plane block ...

At 3 months, chronic pain was reported in 21/56 (37.5%) and 28/58 (48.3%) patients in the ESPB and control groups, respectively (OR = 1.6; 95% ...

Erector Spinae Plane Block for Chronic Lumbosacral Pain

Following the ESP block, the patient reported a significant reduction in his low back pain, with approximately 90% improvement in his pain ...

Erector Spinae Plane Block and Chronic Pain - PMC

A recent study published in the British Journal of Anaesthesia showed that the ESP block was as effective as a paravertebral block in reducing both the acute ...

Erector Spinae Plane Block - StatPearls - NCBI Bookshelf

The erector spinae plane block can be used to deliver regional analgesia for a wide range of surgical procedures in the anterior, posterior, and ...

Effectiveness and Safety of Erector Spinae Plane Block vs. ...

Erector spinae plane block did not improve postoperative pain-related outcomes and recovery after video-assisted thoracoscopic surgery: A randomised ...

Comparison of the efficacy of erector spinae plane block ...

In this study, 0.25% bupivacaine was found to have a clinical effect on postoperative pain. Similarly, several studies have also performed ...

Curb Your Enthusiasm: Erector Spinae Plane Block ...

The ESP group showed a significantly lower VAS pain scores (rest and movement) than the SPB group from 4–6 hours postoperatively. The time for ...

Efficacy and Safety of Erector Spinae Plane Block for ... - PMC

This meta-analysis demonstrated that ESPB used in lumbar spinal surgery was effective in relieving postoperative pain, decreasing the ...

Study Details | NCT07632820 | Erector Spinae Plane Block ...

Participants will receive 5 mL of 0.5% plain bupivacaine per side, with bilateral injections performed when clinically indicated for bilateral thoracic pain.