Anesthesia Strategies for Endotracheal Intubation
(REMI-MEP Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this research is to compare four commonly used anesthesia medication strategies for placing a breathing tube in patients undergoing spine surgery that requires motor evoked potential (MEP) monitoring.
Who Is on the Research Team?
Shaun Gruenbaum, MD
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
This trial is for adults scheduled for spine surgery who need a breathing tube placed and require motor evoked potential (MEP) monitoring. People with conditions that make anesthesia unsafe or those not needing MEP monitoring are excluded.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Trial Overview
The study compares four ways to help place a breathing tube: low-dose remifentanil, high-dose remifentanil (both without muscle relaxants), rocuronium with sugammadex, and succinylcholine. Patients are randomly assigned to one of these groups.
How Is the Trial Designed?
4
Treatment groups
Experimental Treatment
Active Control
Participants receive remifentanil 2 mcg/kg intravenous bolus after standardized propofol induction.
Participants receive remifentanil 4 mcg/kg intravenous bolus after standardized propofol induction.
Participants receive succinylcholine 1 mg/kg intravenous bolus after standardized propofol induction.
Participants receive rocuronium 0.6 mg/kg intravenous bolus after standardized propofol induction, followed by sugammadex reversal after intubation according to protocol.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
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