BL-M14D1 + Atezolizumab for Small Cell Lung Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
The objective of the study is to evaluate the efficacy and safety of BL-M14D1 in combination with Atezolizumab compared to Standard-of-Care Therapy in adult participants with previously untreated extensive-stage small cell lung cancer (ES-SCLC).
Who Is on the Research Team?
Junliang Cai, MD
Principal Investigator
SystImmune Inc.
Are You a Good Fit for This Trial?
This trial is for adults with newly diagnosed extensive-stage small cell lung cancer who have not received prior treatment. Participants must be healthy enough for chemo and immunotherapy, have at least one tumor that can be measured, good organ function, and be able to carry out daily activities.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Atezolizumab
- BL-M14D1
Trial Overview
The study compares a new drug combo (BL-M14D1 plus Atezolizumab) against the standard treatment (Carboplatin, Etoposide, and Atezolizumab followed by Atezolizumab and Lurbinectedin). Patients are randomly assigned to either group.
How Is the Trial Designed?
3
Treatment groups
Experimental Treatment
Active Control
BL-M14D1: Administered on days 1 of every 21 days Atezolizumab: Administered dose on days 1 of every 21 days
BL-M14D1: Administered on days 1 of every 21 days Atezolizumab: Administered dose on days 1 of every 21 days
Medications used in the Control Arm should be administered per local label or institutional guidelines. Induction therapy (4 cycles): Carboplatin (AUC of 5 mg/mL\*min IV) on Day 1 of each 21-day cycle Etoposide (100 mg/m2 IV) on Days 1 through 3 of each 21-day cycle Atezolizumab (1200 mg) IV on Day 1 of each 21-day cycle Maintenance therapy (continues until discontinuation criteria are met): Atezolizumab (1200 mg) IV on Day 1 of each 21-day cycle Lurbinectedin (3.2 mg/m2) IV on Day 1 of each 21-day cycle (to be added only if approved in region and as per PI discretion)
Find a Clinic Near You
Who Is Running the Clinical Trial?
SystImmune Inc.
Lead Sponsor
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