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Transdermal Estradiol for Turner Syndrome

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Overseen ByKimberly Pitner, MSHS, BSN, RN
Age: < 18
Sex: Female
Trial Phase: Phase 2
Sponsor: Children's National Research Institute
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

This is a research study to find out if treatment with transdermal estradiol patches started between 8 to 11.5 years is safe in girls with Turner syndrome who have ovarian failure and to see whether it may improve performance on two tests of working speed and short-term memory.

Are You a Good Fit for This Trial?

Inclusion Criteria

Provision of signed and dated informed consent form
I am a girl aged 8 to 11 with confirmed Turner syndrome.
FSH result > 10 mIU/mL in the past 12 months, with a single measure >10 mIU/mL sufficient for inclusion
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Exclusion Criteria

Any clinically significant abnormality as determined by the principal investigator
I do not have severe cognitive impairment that would affect study assessments.
I have been exposed to estrogen before.
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What Are the Treatments Tested in This Trial?

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Estradiol TreatmentExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Children's National Research Institute

Lead Sponsor

Trials
227
Recruited
258,000+

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