Topical Timolol for Mohs Surgery Wounds

This trial aims to determine if a gel called topical timolol can speed up healing and improve the appearance of scalp wounds after Mohs surgery, a common skin cancer treatment. Participants will either apply topical timolol or follow standard wound care for their surgery wounds. The trial will assess wound healing speed, cosmetic outcomes, and the frequency of unexpected doctor visits. Individuals who have undergone Mohs surgery on their scalp and whose wounds are healing naturally may be suitable for this study. As a Phase 2 trial, this research measures the treatment's effectiveness in an initial, smaller group, allowing participants to contribute to significant medical advancements.

The trial information does not specify if you need to stop taking your current medications. However, if you have conditions like asthma, severe COPD, or certain heart issues, you may not be eligible to participate.

Research has shown that using topical timolol on wounds, including surgical ones, is generally safe. Studies have found it aids in healing wounds such as leg ulcers and those from Mohs surgery. In these studies, patients reported no major side effects, indicating that topical timolol is well-tolerated.

Unlike the standard of care for Mohs surgery wounds, which typically involves saline or other traditional wound care treatments, topical timolol offers a unique approach by using a beta-blocker in a topical form. Researchers are excited because timolol, commonly used in eye drops for glaucoma, may help improve wound healing due to its vasoconstrictive properties, potentially reducing scarring and promoting faster recovery. This method of application is non-invasive and may provide a more effective healing process compared to standard treatments.

Research has shown that topical timolol might help wounds heal faster after Mohs surgery. Some studies found that it can speed up healing and improve scar appearance. In this trial, participants in the Timolol Arm will receive topical timolol treatment, which reduces swelling and encourages skin cells to move to the wound for repair. Meanwhile, participants in the Standard of Care Arm will receive normal saline/standard care treatment. However, not all research agrees; some studies suggest it might not significantly impact healing for everyone.²³⁴⁶⁷