Testosterone Treatment for Chronic Kidney Disease

This trial examines how an oral testosterone treatment called JATENZO affects testosterone levels and red blood cells in men with both low testosterone and chronic kidney disease. Researchers aim to determine if taking JATENZO daily for six months can improve these conditions. Suitable candidates for this trial have chronic kidney disease, low testosterone levels (less than 300 ng/dl), and symptoms such as low sex drive, tiredness, or mood changes. As a Phase 2 trial, this research focuses on measuring the treatment's effectiveness in an initial, smaller group of participants.

The trial does not specify if you need to stop all current medications, but you cannot participate if you are using testosterone replacement therapy or certain other treatments like erythropoiesis stimulating agents or warfarin.

Research has shown that Jatenzo, a pill for increasing testosterone, is usually well-tolerated by patients. In earlier studies, very few participants experienced side effects. For instance, only one participant left a study due to a pre-existing kidney problem.

The FDA has approved Jatenzo for treating low testosterone in men, indicating a certain level of safety. However, limited information exists about its long-term safety, such as potential risks for heart issues or prostate cancer. Participants should consider this when deciding to join a trial.

Unlike the standard treatments for chronic kidney disease, which often focus on managing symptoms or slowing disease progression through medications like ACE inhibitors and ARBs, Jatenzo offers a novel approach by utilizing testosterone therapy. Researchers are excited about Jatenzo because it is an oral testosterone replacement, which could improve energy levels and muscle mass in patients with chronic kidney disease, who often suffer from low testosterone levels. This treatment's unique delivery as a pill is particularly appealing, as it offers a convenient alternative to testosterone injections or gels, making it easier for patients to adhere to the treatment regimen.

Research has shown that Jatenzo, a pill for boosting testosterone, can help men with low testosterone and chronic kidney disease. Studies found that men taking Jatenzo had higher testosterone levels, which can increase energy and muscle strength. Long-term use of testosterone therapy has also been linked to improved kidney function in these men. Most patients report feeling healthier and more satisfied after using Jatenzo for a few months. These findings suggest that Jatenzo could be a promising treatment for men with low testosterone and chronic kidney disease.¹³⁴⁵⁶