HP 129Xe MRI for Lung Transplant Rejection

This trial tests a new method for assessing lung function in individuals who have undergone a double lung transplant. Researchers use a special type of MRI with hyperpolarized 129Xe gas (also known as XENOVIEW or Hyperpolarized Xenon-129) to detect changes in the lungs. The trial targets both stable transplant patients and those with CLAD, a type of chronic lung problem. Candidates may qualify if they have had a double lung transplant, have been stable for over a year, and do not require daily supplemental oxygen. As a Phase 2 trial, this research measures the treatment's effectiveness in an initial, smaller group, providing an opportunity to contribute to significant advancements in post-transplant care.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your healthcare provider.

Research shows that hyperpolarized 129Xenon (129Xe) is generally safe and well-tolerated for lung imaging. Studies have demonstrated that using 129Xe in MRI scans can assess lung function without causing harmful effects. It acts as a contrast agent, enhancing the visibility of lung structures during the scan.

One study found that the FDA approved the process used to prepare 129Xe, further supporting its safety. Although not all studies focused solely on safety, they reported no negative effects from using 129Xe. This suggests that inhaling 129Xe for MRI scans is safe for patients, even those who have had lung transplants.

Researchers are excited about the use of hyperpolarized 129Xenon (129Xe) MRI for lung transplant rejection because it offers a unique way to detect and monitor this condition. Unlike traditional methods, which rely on invasive biopsies or imaging techniques with limited sensitivity, 129Xe MRI allows for a non-invasive, detailed visualization of lung function and gas exchange. This technique uses hyperpolarized 129Xe gas that participants inhale, providing clearer and more precise images of lung tissues, potentially identifying rejection earlier and more accurately. This novel approach could lead to quicker interventions and better outcomes for lung transplant recipients.

Research has shown that hyperpolarized xenon-129 MRI effectively assesses lung function. Studies have found it can identify areas in the lungs that aren't working properly. For lung transplant patients, this technique helps detect changes in lung structure and function. One study found that this method is safe and provides clear images of lung performance. These findings suggest that xenon-129 MRI could be a valuable tool for monitoring lung health after a transplant. Participants in this trial will inhale hyperpolarized 129Xe gas to evaluate its effectiveness in monitoring lung transplant rejection.¹²³⁶⁷