Dexamethasone for Postoperative Pain
What You Need to Know Before You Apply
What is the purpose of this trial?
Possible participants will be scheduled to have 2 gum flap surgeries done on 2 similar surgical sites in the mouth. The study looks at two different ways of giving dexamethasone, a medication used to reduce inflammation. The researchers want to learn if taking dexamethasone by mouth works similarly to receiving dexamethasone through the participant's vein (intravenous, or IV) in reducing short-term pain, swelling, and pain medication after periodontal (gum) flap surgery.
The periodontal evaluation, treatment planning, IV sedation, gum surgery, sutures, and usual postoperative care are part of standard care and would be done even if a participant does not join the study. After joining the study, participants will be randomly assigned to the order in which they receive dexamethasone. At one surgery, participants will receive IV dexamethasone plus oral placebo (an inactive substance that looks the same but does not contain dexamethasone). At the next surgery, participants will receive oral dexamethasone plus IV placebo. As part of the study, participants will be asked to record your pain, swelling and any other medication use.
Who Is on the Research Team?
Mostafa Shehabeldin, DDS, MS, PhD
Principal Investigator
The University of Texas Health Science Center at San Antonio
Angela Paliaologou-Gallis, DDS
Principal Investigator
The University of Texas Health Science Center at San Antonio
Are You a Good Fit for This Trial?
This trial is for people scheduled to have two gum flap surgeries in their mouth. Participants must be able to take both oral and IV medications, and will need to record their pain and swelling after surgery.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Dexamethasone Capsule
- Dexamethasone IV injection
Trial Overview
The study compares dexamethasone given by mouth versus through an IV to see which works better at reducing short-term pain and swelling after gum surgery. Each participant receives both forms of the drug at different surgeries, with placebos used for comparison.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Surgery 1: Oral Dexamethasone plus IV placebo Surgery 2: IV Dexamethasone plus oral placebo
Surgery 1: IV Dexamethasone plus oral placebo Surgery 2: Oral Dexamethasone plus IV placebo
Find a Clinic Near You
Who Is Running the Clinical Trial?
The University of Texas Health Science Center at San Antonio
Lead Sponsor
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