Cannabidiol for Arthritis

KD
WM
Overseen ByWilliam Mihalko, MD, PhD
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

Osteoarthritis of the knee is a common cause of pain in the US. The currently available medicines for knee osteoarthritis sometimes are not effective at relieving the pain or have unacceptable side effects. Thus, alternate pain relieving treatments are needed.

CBD, an active chemical from the hemp derived cannabis sativa plant, has received a lot of attention for its potential pain relieving properties, but there has been limited research to find out if topically applied CBD can decrease pain from knee osteoarthritis. CBD lacks the psychoactive effects seen with marijuana use, because it does not contain THC which is responsible for those effects in marijuana. It is legal to use CBD in the State of Tennessee (site of study).

The CBD Knee Study is sponsored by the University of Tennessee Health Science Center and is a collaborative effort between doctors at UT and Campbell Clinic. In the CBD Knee Study, the investigators are examining whether topically applied CBD dissolved in Castor Oil will relieve knee pain in persons with knee osteoarthritis.

Persons who take part in the study would need to come for study visits, fill out questionnaires about their health and knee pain, and would be asked to use the topical study oil on their knees. Taking part in the CBD Knee Study is voluntary.

Who Is on the Research Team?

KC

Karen C Johnson, MD, MPH

Principal Investigator

University of Tennessee

Are You a Good Fit for This Trial?

This trial is for adults with moderate knee osteoarthritis who have significant knee pain (pain score over 4) and are receiving care at a Campbell Clinic Orthopaedics location.

Inclusion Criteria

Receiving treatment at one of the eight Campbell Clinic Orthopaedics locations
I have knee osteoarthritis pain greater than 4 on the pain scale.
I have moderate knee osteoarthritis.

Exclusion Criteria

I take medications that interact with CBD and cannot stop them.
Discretion of the Multiple Principal Investigators for concerns regarding noncompliance with the study intervention
Alcohol consumption > 21 alcoholic drinks each week
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Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2 weeks
1 visit (in-person)

Treatment Phase 1

Participants receive either CBD+Castor Oil or Castor Oil alone for 1 month

4 weeks
2 visits (in-person)

Washout

A 2-week washout period between treatment phases

2 weeks

Treatment Phase 2

Participants receive the alternate treatment (CBD+Castor Oil or Castor Oil alone) for 1 month

4 weeks
2 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks
2 visits (in-person)

What Are the Treatments Tested in This Trial?

Interventions

  • Cannabidiol (CBD)

Trial Overview

The study compares the effects of a CBD oil applied to the skin versus a placebo oil (castor oil) on relieving knee pain from osteoarthritis. Participants are randomly assigned to one of these treatments.

How Is the Trial Designed?

2

Treatment groups

Active Control

Placebo Group

Group I: CBD+Castol OilActive Control1 Intervention
Group II: Castor Oil AlonePlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Tennessee

Lead Sponsor

Trials
202
Recruited
146,000+